TY - JOUR
T1 - Carcinoma in situ in the testis
AU - Rørth, Mikael
AU - Rajpert-De Meyts, Ewa
AU - Andersson, Lennart
AU - Dieckmann, Klaus Peter
AU - Fosså, Sophie D.
AU - Grigor, Kenneth M.
AU - Hendry, William F.
AU - Herr, Harry W.
AU - Looijenga, Leendert H.J.
AU - Oosterhuis, J. Wolter
AU - Skakkebaek, Niels E.
N1 - Funding Information:
The authors thank Dr G. Bosl for critical comments. Drs H. Lauke and A. F. Holstein for excellent photographs of electron-microscopic and seminthin preparations. The research summarized in this review was supported in part by the Danish Cancer Society, and other national and international organizations.
PY - 2000
Y1 - 2000
N2 - Carcinoma in situ (CIS) of the testis is a common precursor of germ-cell tumours in adults and adolescents, with the exception of spermatocytic seminoma. This article reviews existing knowledge on the pathobiology, genetic aspects and epidemiology of CIS, discusses current hypotheses concerning pathogenesis and invasive progression of germ-cell neoplasms and provides guidelines for diagnosis and clinical management of CIS.
AB - Carcinoma in situ (CIS) of the testis is a common precursor of germ-cell tumours in adults and adolescents, with the exception of spermatocytic seminoma. This article reviews existing knowledge on the pathobiology, genetic aspects and epidemiology of CIS, discusses current hypotheses concerning pathogenesis and invasive progression of germ-cell neoplasms and provides guidelines for diagnosis and clinical management of CIS.
KW - Carcinoma in situ
KW - Germ cell
KW - Isochromosome i(p12)
KW - Orchidectomy
KW - Radiotherapy
KW - Testicular biopsy
KW - Testicular development
KW - Testicular neoplasms
UR - http://www.scopus.com/inward/record.url?scp=4243579630&partnerID=8YFLogxK
U2 - 10.1080/00365590050509896
DO - 10.1080/00365590050509896
M3 - Article
C2 - 11144894
SN - 0300-8886
VL - 34
SP - 166
EP - 186
JO - Scandinavian Journal of Urology and Nephrology, Supplement
JF - Scandinavian Journal of Urology and Nephrology, Supplement
IS - 205
ER -