Cardiovascular and Pulmonary Challenges After Treatment of Childhood Cancer

Henk Visscher, Maria Otth, E. A.M.(Lieke) Feijen, Paul C. Nathan, Claudia E. Kuehni

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review

7 Citaten (Scopus)


Childhood cancer survivors are at risk for developing cardiovascular disease and pulmonary disease related to cancer treatment. This might not become apparent until many years after treatment and varies from subclinical to life-threatening disease. Important causes are anthracyclines and radiotherapy involving heart, head, or neck for cardiovascular disease, and bleomycin, busulfan, nitrosoureas, radiation to the chest, and lung or chest surgery for pulmonary disease. Most effects are dose dependent, but genetic risk factors have been discovered. Treatment options are limited. Prevention and regular screening are crucial. Survivors should be encouraged to adopt a healthy lifestyle, and modifiable risk factors should be addressed.

Originele taal-2Engels
Pagina's (van-tot)1155-1170
Aantal pagina's16
TijdschriftPediatric Clinics of North America
Nummer van het tijdschrift6
StatusGepubliceerd - dec. 2020


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