TY - JOUR
T1 - Chemokine/chemokine receptor interactions in extramedullary leukaemia of the skin in childhood AML
T2 - Differential roles for CCR2, CCR5, CXCR4 and CXCR7
AU - Faaij, Claudia M.J.M.
AU - Willemze, Annemieke J.
AU - Révész, Tom
AU - Balzarolo, Melania
AU - Tensen, Cornelis P.
AU - Hoogeboom, Manja
AU - Vermeer, Maarten H.
AU - Van Wering, Elisabeth
AU - Zwaan, Christian M.
AU - Kaspers, Gertjan J.L.
AU - Story, Colin
AU - Van Halteren, Astrid G.S.
AU - Vossen, Jaak M.
AU - Egeler, R. Maarten
AU - Van Tol, Maarten J.D.
AU - Annels, Nicola E.
PY - 2010/8
Y1 - 2010/8
N2 - Chemokine receptor/ligand interactions orchestrate the migration of cells to peripheral tissues such as the skin. We analysed chemokine receptor expression by acute myeloid leukaemic (AML) cells present in peripheral blood (n=7), bone marrow (n=6), or skin (n=11) obtained from 15 paediatric AML patients with skin involvement and in 10 AML patients without skin involvement. High percentages of circulating CCR2pos AML cells were only detected in patients with extramedullary disease. Skin-residing AML cells displayed a different set of receptors in situ, namely: CCR5, CXCR4, CXCR7 and CX3CR1. These results suggest the involvement of different chemokine/chemokine receptor interactions in homing and retention of AML blasts in the skin.
AB - Chemokine receptor/ligand interactions orchestrate the migration of cells to peripheral tissues such as the skin. We analysed chemokine receptor expression by acute myeloid leukaemic (AML) cells present in peripheral blood (n=7), bone marrow (n=6), or skin (n=11) obtained from 15 paediatric AML patients with skin involvement and in 10 AML patients without skin involvement. High percentages of circulating CCR2pos AML cells were only detected in patients with extramedullary disease. Skin-residing AML cells displayed a different set of receptors in situ, namely: CCR5, CXCR4, CXCR7 and CX3CR1. These results suggest the involvement of different chemokine/chemokine receptor interactions in homing and retention of AML blasts in the skin.
KW - AML
KW - Chemokines
KW - Paediatric haematology/oncology
UR - http://www.scopus.com/inward/record.url?scp=77955100333&partnerID=8YFLogxK
U2 - 10.1002/pbc.22500
DO - 10.1002/pbc.22500
M3 - Article
C2 - 20582977
AN - SCOPUS:77955100333
SN - 1545-5009
VL - 55
SP - 344
EP - 348
JO - Pediatric Blood and Cancer
JF - Pediatric Blood and Cancer
IS - 2
ER -