Childhood lymphomatoid granulomatosis: A report of 2 cases and review of the literature

Zwanique C.A. Tacke, M. Judith Eikelenboom, R. Jeroen Vermeulen, Marjo S. Van Der Knaap, Anne M. Euser, Paul Van Der Valk, Gertjan J.L. Kaspers

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review

16 Citaten (Scopus)


Lymphomatoid granulomatosis (LG) is a B-cell type lymphoproliferative disease. It mainly affects the lungs but may have extrapulmonary manifestations, especially in the central nervous system. The purpose of this study was to review the pediatric cases in the literature and add 2 new cases to the existing literature. A review of the literature was performed on children (0 to 18 years of age at diagnosis) with pathologically proven LG. We found 47 case reports, which, together with 2 new cases, were systematically analyzed. The median age was 12 years. The main symptoms were general, pulmonary, and neurological. Approximately one third of the patients were immunocompromised. High mortality rate was observed. Pediatric LG is a rare disease, which appears to be more frequently seen in immunocompromised patients, especially patients with leukemia. The disease has a high mortality rate; therefore, aggressive therapy according to a highgrade B-cell lymphoma protocol is justified.

Originele taal-2Engels
Pagina's (van-tot)e416-e422
TijdschriftJournal of Pediatric Hematology/Oncology
Nummer van het tijdschrift7
StatusGepubliceerd - 8 okt. 2014
Extern gepubliceerdJa


Duik in de onderzoeksthema's van 'Childhood lymphomatoid granulomatosis: A report of 2 cases and review of the literature'. Samen vormen ze een unieke vingerafdruk.

Citeer dit