TY - JOUR
T1 - Chlamydia trachomatis and placental inflammation in early preterm delivery
AU - Rours, G. Ingrid J.G.
AU - De Krijger, Ronald R.
AU - Ott, Alewijn
AU - Willemse, Hendrina F.M.
AU - De Groot, Ronald
AU - Zimmermann, Luc J.I.
AU - Kornelisse, Renee F.
AU - Verbrugh, Henri A.
AU - Verkooijen, Roel P.
N1 - Funding Information:
The study was approved by the Medical Ethics Committee for Research on Human Subjects of the Erasmus MC, Rotterdam, the Netherlands.
Funding Information:
Acknowledgments The chorioamnionitis study was funded by the Revolving Fund, Erasmus University MC, Rotterdam, the Netherlands. We thank T.J. Schneider, E. Oschatz, F. Jonkers, N. de Graauw and C.J.A.M. Willemsen for their assistance with the data collection and database. Revolvind Fund, Erasmus MC, Rotterdam, The Netherlands.
PY - 2011/5
Y1 - 2011/5
N2 - Chlamydia trachomatis may infect the placenta and subsequently lead to preterm delivery. Our aim was to evaluate the relationship between the presence of Chlamydia trachomatis and signs of placental inflammation in women who delivered at 32 weeks gestation or less. Setting: placental histology and clinical data were prospectively obtained from 304 women and newborns at the Erasmus MC-Sophia, Rotterdam, the Netherlands. C. trachomatis testing of placentas was done retrospectively using PCR. C. trachomatis was detected in 76 (25%) placentas. Histological evidence of placental inflammation was present in 123 (40%) placentas: in 41/76 (54%) placentas with C. trachomatis versus 82/228 (36%) placentas without C. trachomatis infection (OR 2.1, 95% CI 1.2-3.5). C. trachomatis infection correlated with the progression (P = 0.009) and intensity (P = 0.007) of materno-fetal placental inflammation. C. trachomatis DNA was frequently detected in the placenta of women with early preterm delivery, and was associated with histopathological signs of placental inflammation.
AB - Chlamydia trachomatis may infect the placenta and subsequently lead to preterm delivery. Our aim was to evaluate the relationship between the presence of Chlamydia trachomatis and signs of placental inflammation in women who delivered at 32 weeks gestation or less. Setting: placental histology and clinical data were prospectively obtained from 304 women and newborns at the Erasmus MC-Sophia, Rotterdam, the Netherlands. C. trachomatis testing of placentas was done retrospectively using PCR. C. trachomatis was detected in 76 (25%) placentas. Histological evidence of placental inflammation was present in 123 (40%) placentas: in 41/76 (54%) placentas with C. trachomatis versus 82/228 (36%) placentas without C. trachomatis infection (OR 2.1, 95% CI 1.2-3.5). C. trachomatis infection correlated with the progression (P = 0.009) and intensity (P = 0.007) of materno-fetal placental inflammation. C. trachomatis DNA was frequently detected in the placenta of women with early preterm delivery, and was associated with histopathological signs of placental inflammation.
KW - Chlamydia trachomatis
KW - Placental inflammation
KW - Pregnancy
KW - Prematurity
UR - http://www.scopus.com/inward/record.url?scp=79959722025&partnerID=8YFLogxK
U2 - 10.1007/s10654-011-9569-2
DO - 10.1007/s10654-011-9569-2
M3 - Article
C2 - 21431838
AN - SCOPUS:79959722025
SN - 0393-2990
VL - 26
SP - 421
EP - 428
JO - European Journal of Epidemiology
JF - European Journal of Epidemiology
IS - 5
ER -