Samenvatting
Global investigation of histone marks in acute myeloid leukemia (AML) remains limited. Analyses of 38 AML samples through integrated transcriptional and chromatin mark analysis exposes 2 major subtypes. One subtype is dominated by patients with NPM1 mutations or MLL-fusion genes, shows activation of the regulatory pathways involving HOX-family genes as targets, and displays high self-renewal capacity and stemness. The second subtype is enriched for RUNX1 or spliceosome mutations, suggesting potential interplay between the 2 aberrations, and mainly depends on IRF family regulators. Cellular consequences in prognosis predict a relatively worse outcome for the first subtype. Our integrated profiling establishes a rich resource to probe AML subtypes on the basis of expression and chromatin data.
Originele taal-2 | Engels |
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Pagina's (van-tot) | 1059-1069.e6 |
Tijdschrift | Cell Reports |
Volume | 26 |
Nummer van het tijdschrift | 4 |
DOI's | |
Status | Gepubliceerd - 22 jan. 2019 |
Extern gepubliceerd | Ja |