Chromosome 12q heterozygosity is retained in i(12p)-positive testicular germ cell tumor cells

A. Geurts van Kessel; E. van Drunen; B. de Jong; J. W. Oosterhuis; A. Langeveld; M. P. Mulder

doi:10.1016/0165-4608(89)90154-4

Chromosome 12q heterozygosity is retained in i(12p)-positive testicular germ cell tumor cells

A. Geurts van Kessel, E. van Drunen, B. de Jong, J. W. Oosterhuis, A. Langeveld, M. P. Mulder

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

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Restriction fragment length polymorphism analysis is used to demonstrate that formation of the i(12p) chromosome, characteristic of testicular germ cell tumors, does not lead to loss of heterozygosity of various loci on the q arm of chromosome 12. This result suggests that during the etiology of these tumors, aneuploidization precedes the formation of the i(12p) marker chromosome.

Originele taal-2	Engels
Pagina's (van-tot)	129-134
Aantal pagina's	6
Tijdschrift	Cancer Genetics and Cytogenetics
Volume	40
Nummer van het tijdschrift	1
DOI's	https://doi.org/10.1016/0165-4608(89)90154-4
Status	Gepubliceerd - 1 jul. 1989
Extern gepubliceerd	Ja

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abstract = "Restriction fragment length polymorphism analysis is used to demonstrate that formation of the i(12p) chromosome, characteristic of testicular germ cell tumors, does not lead to loss of heterozygosity of various loci on the q arm of chromosome 12. This result suggests that during the etiology of these tumors, aneuploidization precedes the formation of the i(12p) marker chromosome.",

author = "{Geurts van Kessel}, A. and {van Drunen}, E. and {de Jong}, B. and Oosterhuis, {J. W.} and A. Langeveld and Mulder, {M. P.}",

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AU - Oosterhuis, J. W.

AU - Langeveld, A.

AU - Mulder, M. P.

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AB - Restriction fragment length polymorphism analysis is used to demonstrate that formation of the i(12p) chromosome, characteristic of testicular germ cell tumors, does not lead to loss of heterozygosity of various loci on the q arm of chromosome 12. This result suggests that during the etiology of these tumors, aneuploidization precedes the formation of the i(12p) marker chromosome.

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Chromosome 12q heterozygosity is retained in i(12p)-positive testicular germ cell tumor cells

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