Circumvention of glucocorticoid resistance in childhood leukemia

E. G. Haarman; G. J.L. Kaspers; R. Pieters; M. M.A. Rottier; A. J.P. Veerman

doi:10.1016/j.leukres.2008.02.009

Circumvention of glucocorticoid resistance in childhood leukemia

E. G. Haarman, G. J.L. Kaspers, R. Pieters, M. M.A. Rottier, A. J.P. Veerman

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

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In this study, we determined if in vitro resistance to prednisolone and dexamethasone could be circumvented by cortivazol or methylprednisolone, or reversed by meta-iodobenzylguanidine in pediatric lymphoblastic and myeloid leukemia. As there were strong correlations between the LC50 values (drug concentration inducing 50% leukemic cell kill, LCK) of the different glucocorticoids and median prednisolone/methylprednisolone, prednisolone/dexamethasone and prednisolone/cortivazol LC50 ratios did not differ between the leukemia subtypes, we conclude that none of the glucocorticoids had preferential anti-leukemic activity. Meta-iodobenzylguanidine however, partially reversed glucocorticoid resistance in 19% of the lymphoblastic leukemia samples.

Originele taal-2	Engels
Pagina's (van-tot)	1417-1423
Aantal pagina's	7
Tijdschrift	Leukemia Research
Volume	32
Nummer van het tijdschrift	9
DOI's	https://doi.org/10.1016/j.leukres.2008.02.009
Status	Gepubliceerd - sep. 2008
Extern gepubliceerd	Ja

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title = "Circumvention of glucocorticoid resistance in childhood leukemia",

abstract = "In this study, we determined if in vitro resistance to prednisolone and dexamethasone could be circumvented by cortivazol or methylprednisolone, or reversed by meta-iodobenzylguanidine in pediatric lymphoblastic and myeloid leukemia. As there were strong correlations between the LC50 values (drug concentration inducing 50% leukemic cell kill, LCK) of the different glucocorticoids and median prednisolone/methylprednisolone, prednisolone/dexamethasone and prednisolone/cortivazol LC50 ratios did not differ between the leukemia subtypes, we conclude that none of the glucocorticoids had preferential anti-leukemic activity. Meta-iodobenzylguanidine however, partially reversed glucocorticoid resistance in 19% of the lymphoblastic leukemia samples.",

keywords = "Childhood leukemia, Cortivazol, Glucocorticoid resistance, Meta-iodobenzylguanidine",

author = "Haarman, {E. G.} and Kaspers, {G. J.L.} and R. Pieters and Rottier, {M. M.A.} and Veerman, {A. J.P.}",

note = "Funding Information: This project was supported by the Dutch Cancer Society and EUGIA. We would like to thank, A.J.F. Broekhuizen, D.R. Huismans, A.H. Loonen, and C.H. van Zantwijk for their excellent technical assistance.",

year = "2008",

month = sep,

doi = "10.1016/j.leukres.2008.02.009",

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AU - Haarman, E. G.

AU - Kaspers, G. J.L.

AU - Pieters, R.

AU - Rottier, M. M.A.

AU - Veerman, A. J.P.

N1 - Funding Information: This project was supported by the Dutch Cancer Society and EUGIA. We would like to thank, A.J.F. Broekhuizen, D.R. Huismans, A.H. Loonen, and C.H. van Zantwijk for their excellent technical assistance.

PY - 2008/9

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N2 - In this study, we determined if in vitro resistance to prednisolone and dexamethasone could be circumvented by cortivazol or methylprednisolone, or reversed by meta-iodobenzylguanidine in pediatric lymphoblastic and myeloid leukemia. As there were strong correlations between the LC50 values (drug concentration inducing 50% leukemic cell kill, LCK) of the different glucocorticoids and median prednisolone/methylprednisolone, prednisolone/dexamethasone and prednisolone/cortivazol LC50 ratios did not differ between the leukemia subtypes, we conclude that none of the glucocorticoids had preferential anti-leukemic activity. Meta-iodobenzylguanidine however, partially reversed glucocorticoid resistance in 19% of the lymphoblastic leukemia samples.

AB - In this study, we determined if in vitro resistance to prednisolone and dexamethasone could be circumvented by cortivazol or methylprednisolone, or reversed by meta-iodobenzylguanidine in pediatric lymphoblastic and myeloid leukemia. As there were strong correlations between the LC50 values (drug concentration inducing 50% leukemic cell kill, LCK) of the different glucocorticoids and median prednisolone/methylprednisolone, prednisolone/dexamethasone and prednisolone/cortivazol LC50 ratios did not differ between the leukemia subtypes, we conclude that none of the glucocorticoids had preferential anti-leukemic activity. Meta-iodobenzylguanidine however, partially reversed glucocorticoid resistance in 19% of the lymphoblastic leukemia samples.

KW - Childhood leukemia

KW - Cortivazol

KW - Glucocorticoid resistance

KW - Meta-iodobenzylguanidine

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DO - 10.1016/j.leukres.2008.02.009

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SN - 0145-2126

VL - 32

SP - 1417

EP - 1423

JO - Leukemia Research

JF - Leukemia Research

IS - 9

ER -

Circumvention of glucocorticoid resistance in childhood leukemia

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