Classification of gliomas

Onderzoeksoutput: Hoofdstuk in Boek/Rapport/CongresprocedureHoofdstukpeer review


For almost a century, histopathological evaluation of gliomas has provided the gold standard for classification of these neoplasms. Indeed, the (neuro)pathologist is able to render an unequivocal diagnosis of glioma in most specimens and to indicate low- or high-grade malignant character of the lesion. It is increasingly clear, however, that the traditional histopathological diagnosis lacks the robustness and specificity that is needed for more tailored treatment of glioma patients. Even for the experienced neuropathologist, at least three factors may hamper reaching an unequivocal histopathological diagnosis on glioma tissue: (a) tissue quantity and quality, (b) lack of unequivocal histopathological criteria, and (c) incomplete representation of biology by morphology. Smart integration of information on the underlying molecular aberrations in the diagnosis of gliomas will undoubtedly result in a more sophisticated classification of these tumors. Modern neuropathology is thus rapidly moving toward a combined morphological and molecular approach, the challenge being to implement this approach in an affordable way that optimally serves the individual patients suffering from these neoplasms.

Originele taal-2Engels
TitelEmerging Concepts in Neuro-Oncology
UitgeverijSpringer-Verlag London Ltd
Aantal pagina's18
ISBN van elektronische versie9780857294586
ISBN van geprinte versie0857294571, 9780857294579
StatusGepubliceerd - 1 dec. 2013
Extern gepubliceerdJa


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