TY - JOUR
T1 - Clinical and Viral Factors Associated With Disease Severity and Subsequent Wheezing in Infants With Respiratory Syncytial Virus Infection
AU - RESCEU Investigators
AU - McGinley, Joseph P.
AU - Lin, Gu Lung
AU - Öner, Deniz
AU - Golubchik, Tanya
AU - O'Connor, Daniel
AU - Snape, Matthew D.
AU - Gruselle, Olivier
AU - Langedijk, Annefleur C.
AU - Wildenbeest, Joanne
AU - Openshaw, Peter
AU - Nair, Harish
AU - Aerssens, Jeroen
AU - Bont, Louis
AU - Martinón-Torres, Federico
AU - Drysdale, Simon B.
AU - Pollard, Andrew J.
N1 - © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: [email protected].
PY - 2022/8/12
Y1 - 2022/8/12
N2 - : Respiratory syncytial virus (RSV) causes substantial morbidity and mortality in infants and young children worldwide. Here we evaluated host demographic and viral factors associated with RSV disease severity in 325 RSV-infected infants under 1 year of age from 3 European countries during 2017-2020. Younger infants had a higher clinical severity (ReSViNET) score and were more likely to require hospitalization, intensive care, respiratory support, and/or mechanical ventilation than older infants (<3 months vs 3 to <6 months and 3 to <6 months vs ≥6 months). Older age (≥6 months vs <3 months), higher viral load, and RSV-A were associated with a greater probability of fever. RSV-A and RSV-B caused similar disease severity and had similar viral dynamics. Infants with a more severe RSV infection, demonstrated by having a higher ReSViNET score, fever, and requiring hospitalization and intensive care, were more likely to have developed subsequent wheezing at 1 year of age. CLINICAL TRIALS REGISTRATION: NCT03756766.
AB - : Respiratory syncytial virus (RSV) causes substantial morbidity and mortality in infants and young children worldwide. Here we evaluated host demographic and viral factors associated with RSV disease severity in 325 RSV-infected infants under 1 year of age from 3 European countries during 2017-2020. Younger infants had a higher clinical severity (ReSViNET) score and were more likely to require hospitalization, intensive care, respiratory support, and/or mechanical ventilation than older infants (<3 months vs 3 to <6 months and 3 to <6 months vs ≥6 months). Older age (≥6 months vs <3 months), higher viral load, and RSV-A were associated with a greater probability of fever. RSV-A and RSV-B caused similar disease severity and had similar viral dynamics. Infants with a more severe RSV infection, demonstrated by having a higher ReSViNET score, fever, and requiring hospitalization and intensive care, were more likely to have developed subsequent wheezing at 1 year of age. CLINICAL TRIALS REGISTRATION: NCT03756766.
KW - disease severity
KW - respiratory syncytial virus
KW - subgroup
KW - viral load
KW - wheezing
KW - Severity of Illness Index
KW - Humans
KW - Respiratory Syncytial Virus, Human
KW - Respiratory Syncytial Virus Infections/complications
KW - Infant
KW - Hospitalization
KW - Respiratory Sounds/etiology
UR - http://www.scopus.com/inward/record.url?scp=85136342993&partnerID=8YFLogxK
U2 - 10.1093/infdis/jiac163
DO - 10.1093/infdis/jiac163
M3 - Article
C2 - 35902389
AN - SCOPUS:85136342993
SN - 1537-6613
VL - 226
SP - S45-S54
JO - The Journal of infectious diseases
JF - The Journal of infectious diseases
IS - Suppl 1
ER -