TY - JOUR
T1 - Cohort Profile
T2 - LifeLines, a three-generation cohort study and biobank
AU - Scholtens, Salome
AU - Smidt, Nynke
AU - Swertz, Morris A.
AU - Bakker, Stephan J.L.
AU - Dotinga, Aafje
AU - Vonk, Judith M.
AU - Van Dijk, Freerk
AU - Van Zon, Sander K.R.
AU - Wijmenga, Cisca
AU - Wolffenbuttel, Bruce H.R.
AU - Stolk, Ronald P.
N1 - Publisher Copyright:
© The Author 2014.
PY - 2015/8
Y1 - 2015/8
N2 - The LifeLines Cohort Study is a large population-based cohort study and biobank that was established as a resource for research on complex interactions between environmental, phenotypic and genomic factors in the development of chronic diseases and healthy ageing. Between 2006 and 2013, inhabitants of the northern part of The Netherlands and their families were invited to participate, thereby contributing to a three-generation design. Participants visited one of the LifeLines research sites for a physical examination, including lung function, ECG and cognition tests, and completed extensive questionnaires. Baseline data were collected for 167 729 participants, aged from 6 months to 93 years. Follow-up visits are scheduled every 5 years, and in between participants receive follow-up questionnaires. Linkage is being established with medical registries and environmental data. LifeLines contains information on biochemistry, medical history, psychosocial characteristics, lifestyle and more. Genomic data are available including genome-wide genetic data of 15 638 participants. Fasting blood and 24-h urine samples are processed on the day of collection and stored at -80 °C in a fully automated storage facility. The aim of LifeLines is to be a resource for the national and international scientific community. Requests for data and biomaterials can be submitted to the LifeLines Research Office [LLscience@umcg.nl].
AB - The LifeLines Cohort Study is a large population-based cohort study and biobank that was established as a resource for research on complex interactions between environmental, phenotypic and genomic factors in the development of chronic diseases and healthy ageing. Between 2006 and 2013, inhabitants of the northern part of The Netherlands and their families were invited to participate, thereby contributing to a three-generation design. Participants visited one of the LifeLines research sites for a physical examination, including lung function, ECG and cognition tests, and completed extensive questionnaires. Baseline data were collected for 167 729 participants, aged from 6 months to 93 years. Follow-up visits are scheduled every 5 years, and in between participants receive follow-up questionnaires. Linkage is being established with medical registries and environmental data. LifeLines contains information on biochemistry, medical history, psychosocial characteristics, lifestyle and more. Genomic data are available including genome-wide genetic data of 15 638 participants. Fasting blood and 24-h urine samples are processed on the day of collection and stored at -80 °C in a fully automated storage facility. The aim of LifeLines is to be a resource for the national and international scientific community. Requests for data and biomaterials can be submitted to the LifeLines Research Office [LLscience@umcg.nl].
UR - http://www.scopus.com/inward/record.url?scp=84943805392&partnerID=8YFLogxK
U2 - 10.1093/ije/dyu229
DO - 10.1093/ije/dyu229
M3 - Article
C2 - 25502107
AN - SCOPUS:84943805392
SN - 0300-5771
VL - 44
SP - 1172
EP - 1180
JO - International Journal of Epidemiology
JF - International Journal of Epidemiology
IS - 4
ER -