Comparison of conditioning regimens of various intensities for allogeneic hematopoietic SCT using HLA-identical sibling donors in AML and MDS with <10% BM blasts: A report from EBMT

R. Martino, L. De Wreede, M. Fiocco, A. Van Biezen, P. A. Von Dem Borne, R. M. Hamladji, L. Volin, M. Bornhäuser, M. Robin, V. Rocha, T. De Witte, N. Kröger, M. Mohty

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

83 Citaten (Scopus)

Samenvatting

In this multicenter retrospective study, the long-term outcomes of 878 adults with AML and refractory anemia with excess blasts (RAEB) with BM blasts <10% who underwent transplantation with an HLA-identical sibling donor between 1998 and 2004 were analyzed according to four regimens of conditioning intensity: reduced-intensity conditioning (RIC) (either intermediate RIC (IntermRIC) or non-myeloablative (NMA) RIC), and myeloablative conditioning (MC) in 718 patients (either conventional MC or hyperintense MC. In multivariate cox analysis, patients undergoing NMA transplantation had lower non-relapse mortality risk in the first 100 days after transplantation (P<0.01), but a higher risk beyond day +100 (P=0.02), as well as higher relapse incidence in the first 12 months (P<0.01), but the risk was similar in all groups beyond 12 months. The probabilities of PFS and OS up to 7 years were significantly lower only in the NMA subgroup (P≤0.01 for both). The 7-year OS was 53%, 29%, 56% and 51%, respectively. Our data suggest that prospective studies comparing RIC regimens (especially IntermRIC) with MC are appropriate in patients with AML and RAEB who are in a non-advanced disease status.

Originele taal-2Engels
Pagina's (van-tot)761-770
Aantal pagina's10
TijdschriftBone Marrow Transplantation
Volume48
Nummer van het tijdschrift6
DOI's
StatusGepubliceerd - jun. 2013
Extern gepubliceerdJa

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