Consenso multidisciplinar para optimizar la determinación de alteraciones del gen NTRK

Federico Rojo, Ramón Colomer, Fernando López-Ríos, Francisco Bautista, Rosa Álvarez, Enrique de Álava, Raquel Hladun, Pilar Garrido

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review


The recent identification of rearrangements of neurotrophic tyrosine receptor kinase (NTRK) genes and the development of specific fusion protein inhibitors, such as larotrectinib and entrectinib, have revolutionized the diagnostic and clinical management of patients presenting with tumours with these alterations. Tumours that harbour NTRK fusions are found in both adults and children and are either rare tumours with common NTRK fusions that may be diagnostic, or more common tumours with rare NTRK fusions. To assess the currently available evidence, 3key Spanish medical societies (the Spanish Society of Medical Oncology (SEOM), the Spanish Society of Pathology (SEAP) and the Spanish Society of Paediatric Haematology and Oncology (SEHOP) have brought together a group of experts to develop a consensus document that includes guidelines on the diagnostic, clinical and therapeutic aspects of NTRK-fusion tumours. It also discusses the challenges related to the routine detection of these genetic alterations in a mostly public health care system.

Vertaalde titel van de bijdrageMultidisciplinary consensus on optimizing the detection of NTRK gene alterations in tumours
Originele taal-2Spaans
Pagina's (van-tot)250-262
Aantal pagina's13
TijdschriftRevista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de Citologia
Nummer van het tijdschrift4
StatusGepubliceerd - 2021
Extern gepubliceerdJa


  • Adult
  • Child
  • Consensus
  • Gene Fusion
  • Humans
  • Neoplasms/genetics
  • Protein Kinase Inhibitors
  • Receptor, trkA/genetics


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