Controlled assembly of macromolecular β-sheet fibrils

Jurgen M. Smeenk; Matthijs B.J. Otten; Jens Thies; David A. Tirrell; Hendrik G. Stunnenberg; Jan C.M. Van Hest

doi:10.1002/anie.200462415

Controlled assembly of macromolecular β-sheet fibrils

Jurgen M. Smeenk, Matthijs B.J. Otten, Jens Thies, David A. Tirrell, Hendrik G. Stunnenberg, Jan C.M. Van Hest

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

140 Citaten (Scopus)

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Blocking out aggregation: Triblock copolymers consisting of a central β-sheet polypeptide block with the repeating [(AlaGly)₃GluGly] _n sequence and poly(ethylene glycol) (PEG) of M_n = 750 g mol^-1 were prepared and the assembly properties in the solid state were investigated. Attachment of PEG prevented the macroscopic aggregation of the β-sheet polypeptide portion and, instead, resulted in the formation of well-defined fibrils. (Figure Presented).

Originele taal-2	Engels
Pagina's (van-tot)	1968-1971
Aantal pagina's	4
Tijdschrift	Angewandte Chemie - International Edition
Volume	44
Nummer van het tijdschrift	13
DOI's	https://doi.org/10.1002/anie.200462415
Status	Gepubliceerd - 18 mrt. 2005
Extern gepubliceerd	Ja

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title = "Controlled assembly of macromolecular β-sheet fibrils",

abstract = "Blocking out aggregation: Triblock copolymers consisting of a central β-sheet polypeptide block with the repeating [(AlaGly)3GluGly] n sequence and poly(ethylene glycol) (PEG) of Mn = 750 g mol-1 were prepared and the assembly properties in the solid state were investigated. Attachment of PEG prevented the macroscopic aggregation of the β-sheet polypeptide portion and, instead, resulted in the formation of well-defined fibrils. (Figure Presented).",

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AU - Thies, Jens

AU - Tirrell, David A.

AU - Stunnenberg, Hendrik G.

AU - Van Hest, Jan C.M.

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AB - Blocking out aggregation: Triblock copolymers consisting of a central β-sheet polypeptide block with the repeating [(AlaGly)3GluGly] n sequence and poly(ethylene glycol) (PEG) of Mn = 750 g mol-1 were prepared and the assembly properties in the solid state were investigated. Attachment of PEG prevented the macroscopic aggregation of the β-sheet polypeptide portion and, instead, resulted in the formation of well-defined fibrils. (Figure Presented).

KW - Conjugation

KW - Fibers

KW - Peptides

KW - Polymers

KW - Self-assembly

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Controlled assembly of macromolecular β-sheet fibrils

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