Covariate-based dose individualization of the cytotoxic drug indisulam to reduce the risk of severe myelosuppression

Keyphrases

• Cytotoxic Drugs 100%
• Myelosuppression 100%
• Indisulam 100%
• Dose Individualization 100%
• Pharmacokinetics 40%
• Pharmacodynamics 40%
• Genotype 40%
• Treatment Optimization 40%
• CYP2C 40%
• Chemotherapy 20%
• Patient-specific 20%
• Body Surface Area 20%
• Dosing Algorithm 20%
• Dosing Strategy 20%
• Physical Condition 20%
• Nonlinear Mixed Effects 20%
• Patients at Risk 20%
• Treatment Algorithm 20%
• Relative Risk 20%
• Co-medication 20%
• Prior Treatment 20%
• Patient Subgroups 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Cytotoxic Agent 100%
• Bone Marrow Suppression 100%
• Indisulam 100%
• Pharmacodynamics 40%
• Cytochrome P450 2C 40%
• Pharmacokinetics 40%
• Chemotherapy 20%
• Elimination 20%