CRISPR/Cas 9 genome editing and its applications in organoids

Else Driehuis; Hans Clevers

doi:10.1152/ajpgi.00410.2016

CRISPR/Cas 9 genome editing and its applications in organoids

Else Driehuis, Hans Clevers

Group Clevers

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel recenseren › peer review

111 Citaten (Scopus)

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Organoids are threedimensional (3D) structures derived from adult or embryonic stem cells that maintain many structural and functional features of their respective organ. Recently, genome editing based on the bacterial defense mechanism CRISPR/Cas9 has emerged as an easily applicable and reliable laboratory tool. Combining organoids and CRISPR/Cas9 creates exciting new opportunities to study organ development and human disease in vitro. The potential applications of CRISPR in organoids are only beginning to be explored.

Originele taal-2	Engels
Pagina's (van-tot)	G257-G265
Tijdschrift	American Journal of Physiology - Gastrointestinal and Liver Physiology
Volume	312
Nummer van het tijdschrift	3
DOI's	https://doi.org/10.1152/ajpgi.00410.2016
Status	Gepubliceerd - 10 mrt. 2017

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CRISPR/Cas 9 genome editing and its applications in organoids

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