Cyclin A is a prognostic indicator in early stage breast cancer with and without tamoxifen treatment

R. Michalides, H. Van Tinteren, A. Balkenende, J. B. Vermorken, J. Benraadt, J. Huldij, P. Van Diest

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80 Citaten (Scopus)

Samenvatting

Overexpression of G I-S regulators cyclin D I or cyclin A is frequently observed in breast cancer and is also to result in ligand-independent activation of oestrogen receptor in vitro. This might therefore, provide a mechanism for failure of tamoxifen treatment. We examined by immunohistochemical staining the effect of deregulation of these, and other cell cycle regulators on tamoxifen treatment in a group of 394 patients with early stage breast cancer. In univariate analysis, expression of cyclin A, Neu, Ki-67 index, and lack of OR expression were significantly associated with worse prognosis. When adjusted by the clinical model (for lymph node status, age, performance status, T-classification, grade, prior surgery, oestrogen receptor status and tamoxifen use), only overexpression of cyclin A and Neu were significantly associated with worse prognosis with hazard ratios of, respectively, 1.709 (P=0.0195) and 1.884 (P=0.0151). Overexpression of cyclin A was found in 86 out of the 201 OR positive cases treated with tamoxifen, and was the only independent marker associated with worse prognosis (hazard ratio 2.024, P=0.0462). In conclusion, cyclin A is an independent predictor of recurrence of early stage breast cancer and is as such a marker for response in patients treated with tamoxifen.

Originele taal-2Engels
Pagina's (van-tot)402-408
Aantal pagina's7
TijdschriftBritish Journal of Cancer
Volume86
Nummer van het tijdschrift3
DOI's
StatusGepubliceerd - 2002
Extern gepubliceerdJa

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