Samenvatting
The possible relationship among malignancy, differentiation, and chromosomal constitution of primary embryo-derived tumors was studied. Tumors were induced by transplanting 7-day-old mouse embryos under the kidney capsule of syngeneic BALB/c recipients. Transplantation of 101 embryos resulted in 81 tumor-bearing mice: 36 teratocarcinomas; 18 teratomas; and 27 yolk sac tumors. Some of the yolk sac tumors proved to be retransplantable for several generations. Cytogenetic investigation of the primary embryo-derived tumors revealed that the majority of teratocarcinomas (82%) were chromosomally normal, whereas almost all (83%) karyotyped teratomas and yolk sac tumors had a highly abnormal chromosomal constitution. Most common aberrations were polyploidy; overrepresentation of chromosome 1, 6,15, or 19; and an underrepresentation of chromosome 2, 4, 14, or a sex chromosome.
| Originele taal-2 | Engels |
|---|---|
| Pagina's (van-tot) | 3416-3421 |
| Aantal pagina's | 6 |
| Tijdschrift | Cancer Research |
| Volume | 50 |
| Nummer van het tijdschrift | 11 |
| Status | Gepubliceerd - 1 jun. 1990 |
| Extern gepubliceerd | Ja |