TY - JOUR
T1 - Cytogenetic analysis of the mature teratoma and the choriocarcinoma component of a testicular mixed nonseminomatous germ cell tumor
AU - de Graaff, Willem E.
AU - Wolter Oosterhuis, J.
AU - de Jong, Bauke
AU - van Echten-Arends, Jannie
AU - Wiersema-Buist, Janneke
AU - Koops, Heimen Schraffordt
AU - Sleijfer, Dirk Th
N1 - Funding Information:
This study was supported by The Netherlands Cancer Foundation, by Grant No. 88-10, and a grant from the Jan Kornelis de Cock-Stichting, Groningen, The Netherlands. The authors thank Dr. A. J. H. Suurmeijer, Diakonessen Ziekenhuis Groningen, the Netherlands, for sharing his material.
PY - 1992/7/1
Y1 - 1992/7/1
N2 - We karyotyped two histologically distinct components with different metastatic behavior of a testicular nonseminomatous germ cell tumor. The two components showed an almost identical chromosomal pattern. These almost identical karyotypes of the two components with different metastatic potential suggest that the difference in biologic behavior might result from subtle differences (on microscopic or submicroscopic level) in chromosomal pattern or that these differences are predominantly epigenetically determined and depend primarily on the lineage of differentiation of the tumor component. Trophoblastic differentiation results in an aggressive, angioinvasive tumor but in development of teratoma in a tumor with low malignant potential.
AB - We karyotyped two histologically distinct components with different metastatic behavior of a testicular nonseminomatous germ cell tumor. The two components showed an almost identical chromosomal pattern. These almost identical karyotypes of the two components with different metastatic potential suggest that the difference in biologic behavior might result from subtle differences (on microscopic or submicroscopic level) in chromosomal pattern or that these differences are predominantly epigenetically determined and depend primarily on the lineage of differentiation of the tumor component. Trophoblastic differentiation results in an aggressive, angioinvasive tumor but in development of teratoma in a tumor with low malignant potential.
UR - http://www.scopus.com/inward/record.url?scp=0026627768&partnerID=8YFLogxK
U2 - 10.1016/0165-4608(92)90373-G
DO - 10.1016/0165-4608(92)90373-G
M3 - Article
C2 - 1638483
AN - SCOPUS:0026627768
SN - 0165-4608
VL - 61
SP - 67
EP - 73
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 1
ER -