Cytogenetic evidence that carcinoma in situ is the precursor lesion for invasive testicular germ cell tumors

J van Echten; R J van Gurp; M Stoepker; L H Looijenga; J de Jong; W Oosterhuis

doi:10.1016/0165-4608(95)00151-4

Cytogenetic evidence that carcinoma in situ is the precursor lesion for invasive testicular germ cell tumors

J van Echten, R J van Gurp, M Stoepker, L H Looijenga, J de Jong, W Oosterhuis

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

40 Citaten (Scopus)

Samenvatting

A cytogenetic study of two cases of carcinoma in situ of the testis (CIS) and their adjacent invasive tumors, one a nonseminomatous germ cell tumor (NS) and one a seminoma (SE), revealed similarities in chromosomal pattern between the CIS and the invasive lesion in the same patient. These findings present for the first time cytogenetic evidence that CIS of the testis and its adjacent germ cell tumor are clonally related, which suggests that the CIS is indeed the precursor lesion of the invasive tumor.

Originele taal-2	Engels
Pagina's (van-tot)	133-7
Aantal pagina's	5
Tijdschrift	Cancer genetics and cytogenetics
Volume	85
Nummer van het tijdschrift	2
DOI's	https://doi.org/10.1016/0165-4608(95)00151-4
Status	Gepubliceerd - dec. 1995
Extern gepubliceerd	Ja

Toegang tot document

10.1016/0165-4608(95)00151-4

Citeer dit

@article{7c57e0bd6d5142e9b51b490db8d4cd52,

title = "Cytogenetic evidence that carcinoma in situ is the precursor lesion for invasive testicular germ cell tumors",

abstract = "A cytogenetic study of two cases of carcinoma in situ of the testis (CIS) and their adjacent invasive tumors, one a nonseminomatous germ cell tumor (NS) and one a seminoma (SE), revealed similarities in chromosomal pattern between the CIS and the invasive lesion in the same patient. These findings present for the first time cytogenetic evidence that CIS of the testis and its adjacent germ cell tumor are clonally related, which suggests that the CIS is indeed the precursor lesion of the invasive tumor.",

keywords = "Adult, Carcinoma in Situ/genetics, Humans, Karyotyping, Male, Neoplasm Invasiveness, Teratoma/genetics, Testicular Neoplasms/genetics",

author = "{van Echten}, J and {van Gurp}, {R J} and M Stoepker and Looijenga, {L H} and {de Jong}, J and W Oosterhuis",

year = "1995",

month = dec,

doi = "10.1016/0165-4608(95)00151-4",

language = "English",

volume = "85",

pages = "133--7",

journal = "Cancer genetics and cytogenetics",

issn = "0165-4608",

publisher = "Elsevier Inc.",

number = "2",

}

TY - JOUR

T1 - Cytogenetic evidence that carcinoma in situ is the precursor lesion for invasive testicular germ cell tumors

AU - van Echten, J

AU - van Gurp, R J

AU - Stoepker, M

AU - Looijenga, L H

AU - de Jong, J

AU - Oosterhuis, W

PY - 1995/12

Y1 - 1995/12

N2 - A cytogenetic study of two cases of carcinoma in situ of the testis (CIS) and their adjacent invasive tumors, one a nonseminomatous germ cell tumor (NS) and one a seminoma (SE), revealed similarities in chromosomal pattern between the CIS and the invasive lesion in the same patient. These findings present for the first time cytogenetic evidence that CIS of the testis and its adjacent germ cell tumor are clonally related, which suggests that the CIS is indeed the precursor lesion of the invasive tumor.

AB - A cytogenetic study of two cases of carcinoma in situ of the testis (CIS) and their adjacent invasive tumors, one a nonseminomatous germ cell tumor (NS) and one a seminoma (SE), revealed similarities in chromosomal pattern between the CIS and the invasive lesion in the same patient. These findings present for the first time cytogenetic evidence that CIS of the testis and its adjacent germ cell tumor are clonally related, which suggests that the CIS is indeed the precursor lesion of the invasive tumor.

KW - Adult

KW - Carcinoma in Situ/genetics

KW - Humans

KW - Karyotyping

KW - Male

KW - Neoplasm Invasiveness

KW - Teratoma/genetics

KW - Testicular Neoplasms/genetics

UR - http://www.scopus.com/inward/record.url?scp=0029589395&partnerID=8YFLogxK

U2 - 10.1016/0165-4608(95)00151-4

DO - 10.1016/0165-4608(95)00151-4

M3 - Article

C2 - 8548737

SN - 0165-4608

VL - 85

SP - 133

EP - 137

JO - Cancer genetics and cytogenetics

JF - Cancer genetics and cytogenetics

IS - 2

ER -

Cytogenetic evidence that carcinoma in situ is the precursor lesion for invasive testicular germ cell tumors

Samenvatting

Toegang tot document

Vingerafdruk

Citeer dit