Demonstration of the genuine Iso-12p character of the standard marker chromosome of testicular germ cell tumors and identification of further chromosome 12 aberrations by competitive in situ hybridization

R. F. Suijkerbuijk; A. Y. Van De Veen; J. Van Echten; C. H.C.M. Buys; B. De Jong; J. W. Oosterhuis; D. A. Warburton; J. J. Cassiman; D. Schonk; A. Geurts Van Kessel

Demonstration of the genuine Iso-12p character of the standard marker chromosome of testicular germ cell tumors and identification of further chromosome 12 aberrations by competitive in situ hybridization

R. F. Suijkerbuijk, A. Y. Van De Veen, J. Van Echten, C. H.C.M. Buys, B. De Jong, J. W. Oosterhuis, D. A. Warburton, J. J. Cassiman, D. Schonk, A. Geurts Van Kessel

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

70 Citaten (Scopus)

Samenvatting

The recently developed competitive in situ hybridization (CISH) strategy was applied to the analysis of chromosome 12 aberrations in testicular germ cell tumors (TGCTs). DNAs from two rodent-human somatic cell hybrids, containing either a normal chromosome 12 or the p arm of chromosome 12 as their unique human material, were used as probes. Our results demonstrate a genuine iso-12p character of the standard marker chromosome in TGCTs. Moreover, variant markers were identified representing translocation products that also involve chromosome 12.

Originele taal-2	Engels
Pagina's (van-tot)	269-273
Aantal pagina's	5
Tijdschrift	American Journal of Human Genetics
Volume	48
Nummer van het tijdschrift	2
Status	Gepubliceerd - feb. 1991
Extern gepubliceerd	Ja

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Suijkerbuijk, R. F., Van De Veen, A. Y., Van Echten, J., Buys, C. H. C. M., De Jong, B., Oosterhuis, J. W., Warburton, D. A., Cassiman, J. J., Schonk, D., & Geurts Van Kessel, A. (1991). Demonstration of the genuine Iso-12p character of the standard marker chromosome of testicular germ cell tumors and identification of further chromosome 12 aberrations by competitive in situ hybridization. American Journal of Human Genetics, 48(2), 269-273.

@article{ec97906a06b442bda2b84e55830cd1e0,

title = "Demonstration of the genuine Iso-12p character of the standard marker chromosome of testicular germ cell tumors and identification of further chromosome 12 aberrations by competitive in situ hybridization",

abstract = "The recently developed competitive in situ hybridization (CISH) strategy was applied to the analysis of chromosome 12 aberrations in testicular germ cell tumors (TGCTs). DNAs from two rodent-human somatic cell hybrids, containing either a normal chromosome 12 or the p arm of chromosome 12 as their unique human material, were used as probes. Our results demonstrate a genuine iso-12p character of the standard marker chromosome in TGCTs. Moreover, variant markers were identified representing translocation products that also involve chromosome 12.",

author = "Suijkerbuijk, \{R. F.\} and \{Van De Veen\}, \{A. Y.\} and \{Van Echten\}, J. and Buys, \{C. H.C.M.\} and \{De Jong\}, B. and Oosterhuis, \{J. W.\} and Warburton, \{D. A.\} and Cassiman, \{J. J.\} and D. Schonk and \{Geurts Van Kessel\}, A.",

year = "1991",

month = feb,

language = "English",

volume = "48",

pages = "269--273",

journal = "American Journal of Human Genetics",

issn = "0002-9297",

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Suijkerbuijk, RF, Van De Veen, AY, Van Echten, J, Buys, CHCM, De Jong, B, Oosterhuis, JW, Warburton, DA, Cassiman, JJ, Schonk, D & Geurts Van Kessel, A 1991, 'Demonstration of the genuine Iso-12p character of the standard marker chromosome of testicular germ cell tumors and identification of further chromosome 12 aberrations by competitive in situ hybridization', American Journal of Human Genetics, vol. 48, nr. 2, blz. 269-273.

Demonstration of the genuine Iso-12p character of the standard marker chromosome of testicular germ cell tumors and identification of further chromosome 12 aberrations by competitive in situ hybridization. / Suijkerbuijk, R. F.; Van De Veen, A. Y.; Van Echten, J. et al.
In: American Journal of Human Genetics, Vol. 48, Nr. 2, 02.1991, blz. 269-273.

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

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T1 - Demonstration of the genuine Iso-12p character of the standard marker chromosome of testicular germ cell tumors and identification of further chromosome 12 aberrations by competitive in situ hybridization

AU - Suijkerbuijk, R. F.

AU - Van De Veen, A. Y.

AU - Van Echten, J.

AU - Buys, C. H.C.M.

AU - De Jong, B.

AU - Oosterhuis, J. W.

AU - Warburton, D. A.

AU - Cassiman, J. J.

AU - Schonk, D.

AU - Geurts Van Kessel, A.

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N2 - The recently developed competitive in situ hybridization (CISH) strategy was applied to the analysis of chromosome 12 aberrations in testicular germ cell tumors (TGCTs). DNAs from two rodent-human somatic cell hybrids, containing either a normal chromosome 12 or the p arm of chromosome 12 as their unique human material, were used as probes. Our results demonstrate a genuine iso-12p character of the standard marker chromosome in TGCTs. Moreover, variant markers were identified representing translocation products that also involve chromosome 12.

AB - The recently developed competitive in situ hybridization (CISH) strategy was applied to the analysis of chromosome 12 aberrations in testicular germ cell tumors (TGCTs). DNAs from two rodent-human somatic cell hybrids, containing either a normal chromosome 12 or the p arm of chromosome 12 as their unique human material, were used as probes. Our results demonstrate a genuine iso-12p character of the standard marker chromosome in TGCTs. Moreover, variant markers were identified representing translocation products that also involve chromosome 12.

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