Detection of chemotherapy-resistant patient-derived acute lymphoblastic leukemia clones in murine xenografts using cellular barcodes

Keyphrases

• Leukemia 100%
• Acute Lymphoblastic Leukemia 100%
• Patient-derived 100%
• Chemotherapy Resistance 100%
• Murine Xenografts 100%
• Cellular Barcodes 100%
• Chemotherapy 60%
• Methotrexate 60%
• Cellular Barcoding 60%
• Therapy-resistant 40%
• Patient-derived Xenograft 40%
• Relapse Prevention 40%
• Working Diagnosis 20%
• Clonal Dynamics 20%
• Clonal Heterogeneity 20%
• Xenograft 20%
• Paucity 20%
• Leukemia Cells 20%
• Acute Lymphoblastic Leukemia Cells 20%
• NSG Mice 20%
• Response to Chemotherapy 20%
• Single-cell Sequencing Technology 20%
• Clonal Selection 20%
• Placebo 20%
• Clonal Diversity 20%
• Adaptation 20%
• Anatomic Location 20%
• Scid 20%
• Anatomic Site 20%
• Differential Gene Expression 20%
• Clonal Drift 20%
• Selective Pressure 20%
• Clonal Complexity 20%
• End-organ Disease 20%
• Leukemia-initiating Cells 20%
• Barcoding Analysis 20%
• Drug Dependence 20%
• Asymmetric Distribution 20%
• Competitive Dynamics 20%
• Human Patients 20%

Biochemistry, Genetics and Molecular Biology

• Methotrexate 100%
• Dynamics 66%
• Dexamethasone 66%
• NOD SCID Gamma Mouse 33%
• Differential Gene Expression 33%
• Progeny 33%