Development of selective bispecific Wnt mimetics for bone loss and repair

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

22 Citaten (Scopus)

Samenvatting

The Wnt signaling pathway is intricately connected with bone mass regulation in humans and rodent models. We designed an antibody-based platform that generates potent and selective Wnt mimetics. Using this platform, we engineer bi-specific Wnt mimetics that target Frizzled and low-density lipoprotein receptor-related proteins and evaluate their effects on bone accrual in murine models. These synthetic Wnt agonists induce rapid and robust bone building effects, and correct bone mass deficiency and bone defects in various disease models, including osteoporosis, aging, and long bone fracture. Furthermore, when these Wnt agonists are combined with antiresorptive bisphosphonates or anti-sclerostin antibody therapies, additional bone accrual/maintenance effects are observed compared to monotherapy, which could benefit individuals with severe and/or acute bone-building deficiencies. Our data support the continued development of Wnt mimetics for the treatment of diseases of low bone mineral density, including osteoporosis.

Originele taal-2Engels
Artikelnummer3247
TijdschriftNature communications
Volume12
Nummer van het tijdschrift1
DOI's
StatusGepubliceerd - 2021

Vingerafdruk

Duik in de onderzoeksthema's van 'Development of selective bispecific Wnt mimetics for bone loss and repair'. Samen vormen ze een unieke vingerafdruk.

Citeer dit