TY - JOUR
T1 - Diagnosis and management of neonatal leukaemia
AU - Van der Linden, Marieke H.
AU - Creemers, Sara
AU - Pieters, Rob
N1 - Funding Information:
M.H.vdL. is supported by Kinderen Kankervrij (KiKa, project number 1713074).
PY - 2012/8
Y1 - 2012/8
N2 - Leukaemia in neonates (infants <1 month) is rare, whereby neonatal acute myeloid leukaemia (AML) is more frequent than neonatal acute lymphoblastic leukaemia (ALL). High mortality rates are observed, though AML has a better prognosis than ALL. Neonatal leukaemia is typically presented with hepatosplenomegaly, leukaemia cutis and/or hyperleucocytosis. Congenital infections should be ruled out before diagnosis. Rearrangement of the . MLL gene is the most frequently occurring genetic aberration. Treatment includes intensive multi-agent chemotherapy, usually with age-related dose adjustments next to supportive care. Treatment intensification for ALL could be indicated in the future as the dismal prognosis is subject to high relapse rates in ALL.
AB - Leukaemia in neonates (infants <1 month) is rare, whereby neonatal acute myeloid leukaemia (AML) is more frequent than neonatal acute lymphoblastic leukaemia (ALL). High mortality rates are observed, though AML has a better prognosis than ALL. Neonatal leukaemia is typically presented with hepatosplenomegaly, leukaemia cutis and/or hyperleucocytosis. Congenital infections should be ruled out before diagnosis. Rearrangement of the . MLL gene is the most frequently occurring genetic aberration. Treatment includes intensive multi-agent chemotherapy, usually with age-related dose adjustments next to supportive care. Treatment intensification for ALL could be indicated in the future as the dismal prognosis is subject to high relapse rates in ALL.
KW - Acute lymphoblastic leukaemia
KW - Acute myeloid leukaemia
KW - Mixed lineage leukaemia
KW - Neonate
UR - http://www.scopus.com/inward/record.url?scp=84862200420&partnerID=8YFLogxK
U2 - 10.1016/j.siny.2012.03.003
DO - 10.1016/j.siny.2012.03.003
M3 - Review article
C2 - 22510298
AN - SCOPUS:84862200420
SN - 1744-165X
VL - 17
SP - 192
EP - 195
JO - Seminars in Fetal and Neonatal Medicine
JF - Seminars in Fetal and Neonatal Medicine
IS - 4
ER -