Diagnosis and management of neonatal leukaemia

Marieke H. Van der Linden, Sara Creemers, Rob Pieters

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review

46 Citaten (Scopus)

Samenvatting

Leukaemia in neonates (infants <1 month) is rare, whereby neonatal acute myeloid leukaemia (AML) is more frequent than neonatal acute lymphoblastic leukaemia (ALL). High mortality rates are observed, though AML has a better prognosis than ALL. Neonatal leukaemia is typically presented with hepatosplenomegaly, leukaemia cutis and/or hyperleucocytosis. Congenital infections should be ruled out before diagnosis. Rearrangement of the . MLL gene is the most frequently occurring genetic aberration. Treatment includes intensive multi-agent chemotherapy, usually with age-related dose adjustments next to supportive care. Treatment intensification for ALL could be indicated in the future as the dismal prognosis is subject to high relapse rates in ALL.

Originele taal-2Engels
Pagina's (van-tot)192-195
Aantal pagina's4
TijdschriftSeminars in Fetal and Neonatal Medicine
Volume17
Nummer van het tijdschrift4
DOI's
StatusGepubliceerd - aug. 2012
Extern gepubliceerdJa

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