Differential response of SHH-expressing adult medulloblastomas to the sonic hedgehog inhibitor vismodegib: whole-genome analysis

Keyphrases

• Genome Analysis 100%
• Sonic Hedgehog 100%
• Vismodegib 100%
• Differential Response 100%
• Adult Medulloblastoma 100%
• Sonic Hedgehog Inhibitor 100%
• Medulloblastoma 83%
• Adult Patients 33%
• Molecular Subgroups 33%
• Tumor 16%
• Tumor Protein p53 (TP53) 16%
• Wnt Signaling Pathway 16%
• Molecular Analysis 16%
• Targeted Treatment 16%
• Cerebellum 16%
• Gene Expression Profile 16%
• Basal Cell Carcinoma 16%
• Hedgehog Inhibitor 16%
• FDA-approved Drugs 16%
• Primitive Neuroectodermal Tumor 16%
• First-line Therapy 16%
• Chemorefractory 16%
• Cytogenetic Abnormalities 16%
• Sonic Hedgehog Pathway 16%
• Sustained Response 16%
• Molecular Drivers 16%

Medicine and Dentistry

• Medulloblastoma 100%
• Sonic Hedgehog Protein 100%
• Genome Analysis 100%
• Vismodegib 100%
• Hedgehog Signaling 22%
• Neoplasm 11%
• Targeted Therapy 11%
• Gene Expression 11%
• Basal-Cell Carcinoma 11%
• Cerebellum 11%
• Primitive Neuroectodermal Tumor 11%