Diffusion tensor MRI of the spinal cord

Mario Ries, Richard A. Jones, Vincent Dousset, Chrit T.W. Moonen

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

141 Citaten (Scopus)


Apparent diffusion tensor (ADT) measurements on the spinal cord using a pulsed-field-gradient (PFG) multi-shot echo-planar imaging (EPI) sequence are presented. In a study of 10 healthy volunteers, the obtained rotationally invariant anisotropy information is compared to the results obtained by the rotationally dependent methods. The water diffusivity in the direction parallel to the fibers was found to be almost 2.5 times higher than the average diffusivity in directions perpendicular to the fibers and showed cylindrically symmetric anisotropy characteristics. The influence of partial volume effects and the point spread function on the measured results was evaluated, and it was the concluded that a resolution of 1 mm in the read and phase directions is required to obtain unbiased values. Possible clinical implications were demonstrated by investigating the diffusion characteristics of 10 patients suffering from narrowing of the cervical canal. The changes in the diffusion characteristics were found to be large enough to allow a robust detection of diffusion changes in the spine, even in cases in which conventional T2 and T1 weighted images were unable to detect any lesion. (C) 2000 Wiley-Liss, Inc.

Originele taal-2Engels
Pagina's (van-tot)884-892
Aantal pagina's9
TijdschriftMagnetic Resonance in Medicine
Nummer van het tijdschrift6
StatusGepubliceerd - 2000
Extern gepubliceerdJa


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