Direct molecular analysis of a deletion of 3p in tumors from patients with sporadic renal cell carcinoma

Annemarie H. van der Hout, Klaas Kok, Anke van den Berg, J. Wolter Oosterhuis, Ben Carritt, Charles H.C.M. Buys

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

37 Citaten (Scopus)

Samenvatting

Normal and tumorous nephrectomy specimens from seven renal cell carcinoma patients were subjected to a Southern analysis using chromosome #3-specific polymorphic probes. Three patients were not informative because of homozygosity at all loci studied. One patient showing heterozygosity at 3q in normal tissue had a tumor that remained heterozygous. In three patients the tumor showed loss of heterozygosity for a short arm marker at 3p21. In one of them heterozygosity for a second short arm marker was also lost. Another of these three patients retained heterozygosity for this second short arm marker, as well as for a long arm marker, suggesting a chromosomal breakpoint between the loci for the two short arm markers. Our results demonstrate that the known involvement of a short arm region of chromosome #3 in the development of renal cell carcinoma can readily be further evaluated by direct molecular methods.

Originele taal-2Engels
Pagina's (van-tot)281-285
Aantal pagina's5
TijdschriftCancer Genetics and Cytogenetics
Volume32
Nummer van het tijdschrift2
DOI's
StatusGepubliceerd - jun. 1988
Extern gepubliceerdJa

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