Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence

Keyphrases

• Senescence 100%
• ERCC1 100%
• Growth Failure 100%
• Nuclear Abnormalities 100%
• Liver 30%
• Nucleotide Excision Repair 30%
• Kidney 20%
• Early Onset 20%
• Mutant Mice 20%
• Recombination Repair 20%
• DNA Interstrand Crosslinks 20%
• Amino Acids 10%
• Tumorigenesis 10%
• Cell Cycle Arrest 10%
• Polyploidy 10%
• Aging 10%
• Interstrand Crosslink Repair 10%
• Spleen 10%
• Subcutaneous Fat 10%
• Encoded Protein 10%
• Ploidy 10%
• Heterozygosity 10%
• Chemically Induced 10%
• Kidney Disease 10%
• Ferritin 10%
• ERCC1-XPF 10%
• Ultraviolet-induced 10%
• Replicative Senescence 10%
• Interstrand Crosslink 10%
• Invagination 10%
• Truncation 10%
• Structure-specific 10%
• Mutant Phenotype 10%
• Carboxyl Terminus 10%
• Selective Advantage 10%
• Lesion Types 10%
• Truncation mutants 10%
• Reduced Lifespan 10%
• Runting 10%
• DNA nucleotides 10%
• Very Severe 10%

Biochemistry, Genetics and Molecular Biology

• ERCC1 100%
• Base Excision Repair 27%
• Cross-Link 27%
• Nucleotide Excision Repair 27%
• Mouse Mutant 18%
• Recombination Repair 18%
• Amino Acids 9%
• Carcinogenesis 9%
• Polyploid 9%
• Cell Cycle Arrest 9%
• Lifespan 9%
• Endonuclease 9%
• C-Terminus 9%
• Heterozygosity 9%
• Ploidy 9%
• Crosslinking of DNA 9%
• Cell Cycle Checkpoint 9%
• Cytoplasmic Invagination 9%
• Ferritin 9%