Does Weight Impact Anidulafungin Pharmacokinetics?

Vincent J. Lempers; Anne van Rongen; Eric P. van Dongen; Bert van Ramshorst; David M. Burger; Rob E. Aarnoutse; Catherijne A. Knibbe; Roger J. Brüggemann

doi:10.1007/s40262-016-0401-8

Does Weight Impact Anidulafungin Pharmacokinetics?

Vincent J. Lempers, Anne van Rongen, Eric P. van Dongen, Bert van Ramshorst, David M. Burger, Rob E. Aarnoutse, Catherijne A. Knibbe, Roger J. Brüggemann

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

20 Citaten (Scopus)

Samenvatting

Bodyweight has been shown to influence anidulafungin exposure, but data from obese patients are lacking. We determined anidulafungin pharmacokinetics (100-mg single dose) in eight morbidly obese subjects (body mass index >40 kg/m²). Anidulafungin exposure was on average 32.5 % lower compared with the general patient population, suggesting dose increases may be required in this population.

Originele taal-2	Engels
Pagina's (van-tot)	1289-1294
Aantal pagina's	6
Tijdschrift	Clinical Pharmacokinetics
Volume	55
Nummer van het tijdschrift	10
DOI's	https://doi.org/10.1007/s40262-016-0401-8
Status	Gepubliceerd - 1 okt. 2016
Extern gepubliceerd	Ja

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10.1007/s40262-016-0401-8

Citeer dit

@article{2927c20d9222429f90bb72ae290082a4,

title = "Does Weight Impact Anidulafungin Pharmacokinetics?",

abstract = "Bodyweight has been shown to influence anidulafungin exposure, but data from obese patients are lacking. We determined anidulafungin pharmacokinetics (100-mg single dose) in eight morbidly obese subjects (body mass index >40 kg/m2). Anidulafungin exposure was on average 32.5 % lower compared with the general patient population, suggesting dose increases may be required in this population.",

author = "Lempers, {Vincent J.} and {van Rongen}, Anne and {van Dongen}, {Eric P.} and {van Ramshorst}, Bert and Burger, {David M.} and Aarnoutse, {Rob E.} and Knibbe, {Catherijne A.} and Br{\"u}ggemann, {Roger J.}",

note = "Publisher Copyright: {\textcopyright} 2016, The Author(s).",

year = "2016",

month = oct,

day = "1",

doi = "10.1007/s40262-016-0401-8",

language = "English",

volume = "55",

pages = "1289--1294",

journal = "Clinical Pharmacokinetics",

issn = "0312-5963",