Dosage of cisplatin in hyperthermic isolated regional perfusion. An experimental study in dogs

J. De Vries; R. M. Hartel; J. W. Oosterhuis; H. Schraffordt Koops

Dosage of cisplatin in hyperthermic isolated regional perfusion. An experimental study in dogs

J. De Vries, R. M. Hartel, J. W. Oosterhuis, H. Schraffordt Koops

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

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There is no uniformity in the literature about dosage of cytostatics in isolated regional perfusion. We prefer a dosage related to the volume of perfused tissue. Optimal dosage of cisplatin in isolated regional perfusion under hyperthermia was assessed. Two dogs received 45 mg/liter extremity volume causing irreversible tissue damage especially of skeletal muscle. After dose reduction (30%) to 30 mg/liter extremity volume toxicity in 3 dogs was acceptable and reversible. This is considered optimal dosage of cisplatin in isolated regional perfusion. Uniformity in dosimetry of cytostatics in regional perfusion in stressed.

Originele taal-2	Engels
Pagina's (van-tot)	107-112
Aantal pagina's	6
Tijdschrift	Surgical Research Communications
Volume	2
Nummer van het tijdschrift	2
Status	Gepubliceerd - 1987
Extern gepubliceerd	Ja

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title = "Dosage of cisplatin in hyperthermic isolated regional perfusion. An experimental study in dogs",

abstract = "There is no uniformity in the literature about dosage of cytostatics in isolated regional perfusion. We prefer a dosage related to the volume of perfused tissue. Optimal dosage of cisplatin in isolated regional perfusion under hyperthermia was assessed. Two dogs received 45 mg/liter extremity volume causing irreversible tissue damage especially of skeletal muscle. After dose reduction (30%) to 30 mg/liter extremity volume toxicity in 3 dogs was acceptable and reversible. This is considered optimal dosage of cisplatin in isolated regional perfusion. Uniformity in dosimetry of cytostatics in regional perfusion in stressed.",

author = "{De Vries}, J. and Hartel, {R. M.} and Oosterhuis, {J. W.} and {Schraffordt Koops}, H.",

year = "1987",

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journal = "Surgical Research Communications",

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T1 - Dosage of cisplatin in hyperthermic isolated regional perfusion. An experimental study in dogs

AU - De Vries, J.

AU - Hartel, R. M.

AU - Oosterhuis, J. W.

AU - Schraffordt Koops, H.

PY - 1987

Y1 - 1987

N2 - There is no uniformity in the literature about dosage of cytostatics in isolated regional perfusion. We prefer a dosage related to the volume of perfused tissue. Optimal dosage of cisplatin in isolated regional perfusion under hyperthermia was assessed. Two dogs received 45 mg/liter extremity volume causing irreversible tissue damage especially of skeletal muscle. After dose reduction (30%) to 30 mg/liter extremity volume toxicity in 3 dogs was acceptable and reversible. This is considered optimal dosage of cisplatin in isolated regional perfusion. Uniformity in dosimetry of cytostatics in regional perfusion in stressed.

AB - There is no uniformity in the literature about dosage of cytostatics in isolated regional perfusion. We prefer a dosage related to the volume of perfused tissue. Optimal dosage of cisplatin in isolated regional perfusion under hyperthermia was assessed. Two dogs received 45 mg/liter extremity volume causing irreversible tissue damage especially of skeletal muscle. After dose reduction (30%) to 30 mg/liter extremity volume toxicity in 3 dogs was acceptable and reversible. This is considered optimal dosage of cisplatin in isolated regional perfusion. Uniformity in dosimetry of cytostatics in regional perfusion in stressed.

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M3 - Article

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ER -

Dosage of cisplatin in hyperthermic isolated regional perfusion. An experimental study in dogs

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