Dose-dense cisplatin-based chemotherapy and surgery for children with high-risk hepatoblastoma (SIOPEL-4): a prospective, single-arm, feasibility study

Keyphrases

• High Risk 100%
• Preoperative Chemotherapy 100%
• Hepatoblastoma 100%
• Cisplatin-based Chemotherapy 100%
• Dose-dense 100%
• Single-arm Feasibility Study 100%
• SIOPEL 100%
• Doxorubicin 75%
• Complete Remission 75%
• Tumor 50%
• Cisplatin 50%
• Treatment Regimen 50%
• Cancer Research 50%
• Carboplatin 50%
• Chemotherapy Cycles 50%
• Area under the Curve 50%
• Ototoxicity 50%
• Tumor-like Lesions 50%
• Neutropenia 50%
• One-child 50%
• End of Treatment 50%
• Switzerland 25%
• Metastatic Disease 25%
• Event-free Survival 25%
• Alpha-fetoprotein 25%
• Overall Survival 25%
• Mucositis 25%
• Anemia 25%
• Serious Adverse Events 25%
• Intention-to-treat 25%
• After Surgery 25%
• End of Therapy 25%
• Newly Diagnosed 25%
• Abdominal 25%
• Moderate to Severe 25%
• Febrile Neutropenia 25%
• Documented Infection 25%
• Partial Response 25%
• Hematotoxicity 25%
• Gross Total Resection 25%
• Extrahepatic Disease 25%
• Fungal Infection 25%
• Microvascular Invasion 25%
• Liver Metastasectomy 25%
• Liver Transplantation 25%
• Before Surgery 25%
• Anorexia 25%
• Surgical Removal 25%
• Radical Surgery 25%
• Lung Metastasis 25%
• Tumor Rupture 25%
• Hepatectomy 25%
• Liver Segments 25%
• Thrombocytopenia 25%

Medicine and Dentistry

• Neoplasm 100%
• Cisplatin 100%
• Hepatoblastoma 100%
• Arm 100%
• Dose Densification 100%
• Chemotherapy 100%
• Doxorubicin 60%
• Preoperative Chemotherapy 60%
• Cancer Research 40%
• Carboplatin 40%
• Neutropenia 40%
• Ototoxicity 40%
• Disease 20%
• Adverse Event 20%
• Metastatic Carcinoma 20%
• Event Free Survival 20%
• Overall Survival 20%
• Surgery 20%
• Infection 20%
• Side Effect 20%
• Anemia 20%
• Intention-to-Treat Analysis 20%
• Mucositis 20%
• Febrile Neutropenia 20%
• Mycosis 20%
• Hepatectomy 20%
• Liver Transplantation 20%
• Thrombocytopenia 20%
• Anorexia 20%
• Radical Surgery 20%
• Lung Metastasis 20%
• Metastasectomy 20%
• Fetoprotein 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Chemotherapy 100%
• Hepatoblastoma 100%
• Cisplatin 100%
• Neoplasm 83%
• Doxorubicin 50%
• Remission 50%
• Malignant Neoplasm 33%
• Carboplatin 33%
• Neutropenia 33%
• Ototoxicity 33%
• Disease 16%
• Event Free Survival 16%
• Overall Survival 16%
• Infection 16%
• Side Effect 16%
• Mucosa Inflammation 16%
• Mycosis 16%
• Metastasis 16%
• Adverse Event 16%
• Anemia 16%
• Febrile Neutropenia 16%
• Anorexia 16%
• Lung Metastasis 16%
• Fetoprotein 16%
• Thrombocytopenia 16%