Dose-finding studies with carboplatin, ifosfamide, etoposide, and mesna in non-small cell lung cancer

Nico van Zandwijk, Wim W. ten Bokkel Huinink, Jantine Wanders, Godelaine Simonetti, Ria Dubbelman, Hillary Franklin, H. van Tinteren, J. Gordon McVie

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

21 Citaten (Scopus)


Carboplatin, a clinically active analogue of cisplatin, was added to a regimen containing ifosfamide and etoposide, two agents with proven activity in non-small cell lung cancer (NSCLC). From August 1986 until November 1988, 43 consecutive patients (29 men and 14 women), mean age 57 years, performance status of 2 or less, with symptomatic, inoperable NSCLC were accrued and received carboplatin 100 mg/m2 on days 1, 3, and 5, or 300 or 350 mg/m2 on day 1; ifosfamide 1,500 mg/m2 and etoposide 60 or 100 mg/m2 every 4 weeks. Thirty-four patients were previously untreated, nine had been irradiated before, and two had also received previous chemotherapy. So far, 154 courses have been administered; 19 patients have received four or more courses. With the combination of 350 mg/m2 carboplatin and 100 mg/m2 etoposide, myelosuppression was doselimiting; nephrotoxicity and neurotoxicity did not occur. Evaluation of response after two or four courses in 40 patients showed an objective response in 40%, whereas 30% progressed during therapy. Carboplatin added to etoposide and ifosfamide is a feasible combination that warrants further study in a randomized fashion.

Originele taal-2Engels
Pagina's (van-tot)16-19
Aantal pagina's4
TijdschriftSeminars in Oncology
Nummer van het tijdschrift1 SUPPL. 2
StatusGepubliceerd - feb. 1990
Extern gepubliceerdJa


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