Dosing of carboplatin in a patient with amputated legs: A case report

F. Van Gorp, M. Th M. Van Rens, E. M. Kuck, R. Rozemeijer, A. D.R. Huitema, E. E.M. Brouwers

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

5 Citaten (Scopus)

Samenvatting

Carboplatin is a platinum derivative that is commonly used in combination chemotherapy for treatment of several malignancies, including small-cell lung carcinoma (SCLC). Because the estimated glomerular filtration rate, and therefore the carboplatin dose, is based on the serum creatinine level, dosing of carboplatin for amputees is a challenge. This case report describes how serum carboplatin levels were used to determine the most suitable carboplatin dose for an amputee. The patient received four cycles of etoposide in combination with carboplatin area under the curve =5 mg·min/ml, with a dose reduction of 25% and concurrent radiotherapy. The measured area under the curve was found to be 3.41 mg·min/ml, while the target area under the curve was 3.75 mg·min/ml (75% of 5 mg·min/ml). Therefore, for the next cycles, the carboplatin dose was calculated using the Calvert formula. No recurrence of disease was seen within two years after completion of therapy. This case demonstrates that therapeutic drug monitoring can successfully be used to determine the carboplatin dose for an amputee.

Originele taal-2Engels
Pagina's (van-tot)473-475
Aantal pagina's3
TijdschriftJournal of Oncology Pharmacy Practice
Volume20
Nummer van het tijdschrift6
DOI's
StatusGepubliceerd - 20 dec. 2014
Extern gepubliceerdJa

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