Drug-drug interaction between itraconazole and the antiretroviral drug lopinavir/ritonavir in an HIV-1-infected patient with disseminated histoplasmosis.

Kristel M.L. Crommentuyn, Jan W. Mulder, Rolf W. Sparidans, Alwin D.R. Huitema, Jan H.M. Schellens, Jos H. Beijnen

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

33 Citaten (Scopus)

Samenvatting

We describe a drug-drug interaction between coformulated lopinavir/ritonavir and itraconazole in a patient infected with human immunodeficiency virus type 1 who had disseminated histoplasmosis. Coadministration of these agents led to a strong increase in itraconazole concentrations and a decrease in concentrations of its metabolite, hydroxyitraconazole, which is equally active pharmacologically. The dosage of itraconazole was reduced when it was used in combination with lopinavir/ritonavir.

Originele taal-2Engels
Pagina's (van-tot)e73-75
TijdschriftClinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume38
Nummer van het tijdschrift8
DOI's
StatusGepubliceerd - 15 apr. 2004
Extern gepubliceerdJa

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