We describe a drug-drug interaction between coformulated lopinavir/ritonavir and itraconazole in a patient infected with human immunodeficiency virus type 1 who had disseminated histoplasmosis. Coadministration of these agents led to a strong increase in itraconazole concentrations and a decrease in concentrations of its metabolite, hydroxyitraconazole, which is equally active pharmacologically. The dosage of itraconazole was reduced when it was used in combination with lopinavir/ritonavir.
|Tijdschrift||Clinical infectious diseases : an official publication of the Infectious Diseases Society of America|
|Nummer van het tijdschrift||8|
|Status||Gepubliceerd - 15 apr. 2004|