TY - JOUR
T1 - Effect of N‐acetylcysteïne on photofrin‐induced skin photosensitivity in patients
AU - Baas, Paul
AU - van Mansom, Inge
AU - van Tinteren, Harm
AU - Stewart, Fiona A.
AU - van Zandwijk, Nico
PY - 1995
Y1 - 1995
N2 - Background and Objective: One of the major side effects of photodynamic therapy (PDT) employing Photofrin as the sensitizer is enhanced photosensitivity of the skin. The basic mechanism in PDT damage is believed to be the formation of singlet oxygen and radical species. N‐acetylcysteïne (NAC) increases glutathione levels and is known to prevent pathology elicited by radicals and reactive species. Study Design/Materials and Methods: NAC was tested in a randomized, open label study for its protective effect on skin photosensitivity. Twenty‐seven patients treated with PDT for central obstructive lung cancer or esophageal cancer received either “early” or “delayed” NAC, starting 5 or 10 days after Photofrin, in a dose of 3 × 600 mg per day for 5 days. Light, obtained from a halogen lamp (fluence rate 200 mW·cm−2) was used to illuminate skin patches of 2.5 cm2 on the back (10, 25, and 50 J·cm−2). Skin response was measured by using a visual scoring system and by measuring the redness using a reflectance meter. Results: Skin responses varied from no changes at 10 J·cm−2 to redness with edema at energies of 50 J·cm−2. In the absence of edema, measurements with the reflectance meter appeared to be more sensitive than visual scoring. Conclusion: In a limited number of patients, there was a trend for decreased sensitivity after NAC, but statistical analysis failed to show any significant protective effect of this short course of NAC. © 1995 Wiley‐Liss, Inc.
AB - Background and Objective: One of the major side effects of photodynamic therapy (PDT) employing Photofrin as the sensitizer is enhanced photosensitivity of the skin. The basic mechanism in PDT damage is believed to be the formation of singlet oxygen and radical species. N‐acetylcysteïne (NAC) increases glutathione levels and is known to prevent pathology elicited by radicals and reactive species. Study Design/Materials and Methods: NAC was tested in a randomized, open label study for its protective effect on skin photosensitivity. Twenty‐seven patients treated with PDT for central obstructive lung cancer or esophageal cancer received either “early” or “delayed” NAC, starting 5 or 10 days after Photofrin, in a dose of 3 × 600 mg per day for 5 days. Light, obtained from a halogen lamp (fluence rate 200 mW·cm−2) was used to illuminate skin patches of 2.5 cm2 on the back (10, 25, and 50 J·cm−2). Skin response was measured by using a visual scoring system and by measuring the redness using a reflectance meter. Results: Skin responses varied from no changes at 10 J·cm−2 to redness with edema at energies of 50 J·cm−2. In the absence of edema, measurements with the reflectance meter appeared to be more sensitive than visual scoring. Conclusion: In a limited number of patients, there was a trend for decreased sensitivity after NAC, but statistical analysis failed to show any significant protective effect of this short course of NAC. © 1995 Wiley‐Liss, Inc.
KW - N‐acetylcysteïne
KW - photodynamic therappy
KW - skin photosensitivity
UR - http://www.scopus.com/inward/record.url?scp=0028990130&partnerID=8YFLogxK
U2 - 10.1002/lsm.1900160407
DO - 10.1002/lsm.1900160407
M3 - Article
C2 - 7651057
AN - SCOPUS:0028990130
SN - 0196-8092
VL - 16
SP - 359
EP - 367
JO - Lasers in Surgery and Medicine
JF - Lasers in Surgery and Medicine
IS - 4
ER -