TY - JOUR
T1 - Effect of the histone deacetylase inhibitor depsipeptide on B-cell differentiation in both TEL-AML1-positive and negative childhood acute lymphoblastic leukemia
AU - Stams, Wendy A G
AU - den Boer, Monique L
AU - Beverloo, H Berna
AU - Kazemier, Karin M
AU - van Wering, Elisabeth R
AU - Janka-Schaub, Gritta E
AU - Pieters, Rob
PY - 2005/12
Y1 - 2005/12
N2 - The fusion protein TEL-AML1 in t(12;21)+ acute lymphoblastic leukemia (ALL) recruits co-repressors and histone deacetylases (HDAC), which transrepress AML1 target genes. Normal bone marrow cells were more resistant to HDAC inhibitor FK228 induced cell killing than were cells from ALL patients with or without t(12;21). FK228 induced differentiation in ALL, irrespective of the presence of t(12;21).
AB - The fusion protein TEL-AML1 in t(12;21)+ acute lymphoblastic leukemia (ALL) recruits co-repressors and histone deacetylases (HDAC), which transrepress AML1 target genes. Normal bone marrow cells were more resistant to HDAC inhibitor FK228 induced cell killing than were cells from ALL patients with or without t(12;21). FK228 induced differentiation in ALL, irrespective of the presence of t(12;21).
KW - Antibiotics, Antineoplastic/pharmacology
KW - Antigens, Differentiation, B-Lymphocyte/analysis
KW - Antineoplastic Agents/pharmacology
KW - Asparaginase/pharmacology
KW - B-Lymphocytes/drug effects
KW - Bone Marrow Cells/drug effects
KW - Butyrates/pharmacology
KW - Cell Differentiation/drug effects
KW - Core Binding Factor Alpha 2 Subunit/analysis
KW - Depsipeptides/pharmacology
KW - Histone Deacetylase Inhibitors
KW - Humans
KW - Myeloid Cells/drug effects
KW - Oncogene Proteins, Fusion/analysis
KW - Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/enzymology
KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma/enzymology
KW - Tumor Cells, Cultured/drug effects
M3 - Article
C2 - 16330447
SN - 0390-6078
VL - 90
SP - 1697
EP - 1699
JO - Haematologica
JF - Haematologica
IS - 12
ER -