Effects of CIS‐platinum on embryonal carcinoma cell lines in vitro

J. W. Oosterhuis, P. W. Andrews, B. B. Knowles, I. Damjanov

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

38 Citaten (Scopus)


Human and mouse embryonal carcinoma (EC) cells lines were compared with several cell lines of a more differentiated phenotype for their relative sensitivities to the cytotoxic effects of cis‐platinum (cis‐diamine‐dichloroplatinum; CDDP); EC lines were among the most sensitive. Furthermore, several markers of EC cell differentiation were not induced by CDDP, irrespective of the concentration of the drug used. These data provide an explanation for the relative sensitivity of the EC cells in non‐seminomatous germ‐cell tumors to cis‐platinum therapy.

Originele taal-2Engels
Pagina's (van-tot)133-139
Aantal pagina's7
TijdschriftInternational Journal of Cancer
Nummer van het tijdschrift1
StatusGepubliceerd - 15 jul. 1984
Extern gepubliceerdJa


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