Effects of compound heterozygosity at the Xpd locus on cancer and ageing in mouse models

Keyphrases

• Mouse Model 100%
• Aging 100%
• Compound Heterozygous mutation 100%
• Xeroderma pigmentosum 80%
• Trichothiodystrophy 80%
• Cockayne Syndrome 60%
• Mutant Alleles 60%
• Disease Heterogeneity 40%
• Genotype-phenotype Association 40%
• Skin Cancer 40%
• Excision 40%
• UV Radiation 40%
• Heterozygous Mice 40%
• Isogenic 20%
• Genetic Background 20%
• Cancer Predisposition 20%
• Biallelic 20%
• DNA Repair Genes 20%
• Cell Proliferation 20%
• Metabolic 20%
• DNA Repair 20%
• DNA Damage Foci 20%
• Cellular DNA 20%
• Cell Behavior 20%
• Protein Complex 20%
• Segmental Progeria 20%
• TFIIH 20%
• Helicase 20%
• UV-induced DNA Damage 20%
• UV Sensitivity 20%
• Focus Formation 20%
• Recessive Disease 20%
• Sunburn 20%
• Insulin Sensitivity 20%
• Overlap Syndrome 20%
• Metabolic Phenotype 20%
• Interallelic Complementation 20%
• Disease Allele 20%
• Weighted Sensitivity 20%

Biochemistry, Genetics and Molecular Biology

• Allele 100%
• Mouse Model 100%
• Compound Heterozygosity 100%
• Xeroderma pigmentosum 44%
• Powder X-Ray Diffraction 44%
• Cockayne Syndrome 33%
• DNA Damage 22%
• Base Excision Repair 22%
• Nucleotide Excision Repair 22%
• Genotyping 22%
• Genetic Background 11%
• Cell Proliferation 11%
• Transcription 11%
• Body Weight 11%
• Progeria 11%
• Helicase 11%
• Protein Complexes 11%
• Transcription Factor IIH 11%
• Insulin Sensitivity 11%

Neuroscience

• Cockayne Syndrome 100%
• DNA Damage 66%
• Base Excision Repair 66%
• Nucleotide Excision Repair 66%
• In Vivo 33%
• In Vitro 33%
• Cell Proliferation 33%
• Helicase 33%
• Transcription Factor IIH 33%
• Protein Complexes 33%
• Cell DNA 33%