TY - JOUR
T1 - Electroejaculation as a method of fertility preservation in boys diagnosed with cancer
T2 - A single-center experience and review of the literature
AU - Adank, Maria C.
AU - Van Dorp, Wendy
AU - Smit, Marij
AU - Van Casteren, Niels J.
AU - Laven, Joop S.E.
AU - Pieters, Rob
AU - Van Den Heuvel-Eibrink, Marry M.
N1 - Funding Information:
This study was supported by the Pediatric Oncology Center Society for Research (to W.v.D.).
PY - 2014/7
Y1 - 2014/7
N2 - Objective To evaluate the feasibility of electroejaculation to perform semen cryopreservation in pubertal boys before gonadotoxic therapy and to review the literature on this topic. Design Retrospective cohort study and review of the literature. Setting Academic children's hospital. Patient(s) Boys diagnosed with cancer to whom sperm cryopreservation was offered before the start of gonadotoxic therapy. Intervention(s) We studied the outcome of electroejaculation, including patient characteristics, hormone levels, and pretreatment semen parameters. Main Outcome Measure(s) Semen cryopreservation. Result(s) Pretreatment semen samples were obtained by masturbation in 106/114 boys with cancer, of which 78/106 were adequate for preservation. Electroejaculation was offered to 11 boys, of which three of 11 samples appeared adequate for preservation. Reviewing all reported electroejaculation cases in children with cancer in the literature, 13/29 (45%) cases were successful. Testosterone levels were higher in patients with successful sperm yield obtained by electroejaculation (median, 8.3 nmol/L [5.2-42.4] in successful harvests, vs. median 1.7 nmol/L [0.01-17.9] in unsuccessful harvests). Conclusion(s) Semen cryopreservation should be offered to all pubertal boys diagnosed with cancer. If masturbation fails, electroejaculation can be considered as a useful option for semen cryopreservation and leads to adequate material for cryopreservation in about half of the cases.
AB - Objective To evaluate the feasibility of electroejaculation to perform semen cryopreservation in pubertal boys before gonadotoxic therapy and to review the literature on this topic. Design Retrospective cohort study and review of the literature. Setting Academic children's hospital. Patient(s) Boys diagnosed with cancer to whom sperm cryopreservation was offered before the start of gonadotoxic therapy. Intervention(s) We studied the outcome of electroejaculation, including patient characteristics, hormone levels, and pretreatment semen parameters. Main Outcome Measure(s) Semen cryopreservation. Result(s) Pretreatment semen samples were obtained by masturbation in 106/114 boys with cancer, of which 78/106 were adequate for preservation. Electroejaculation was offered to 11 boys, of which three of 11 samples appeared adequate for preservation. Reviewing all reported electroejaculation cases in children with cancer in the literature, 13/29 (45%) cases were successful. Testosterone levels were higher in patients with successful sperm yield obtained by electroejaculation (median, 8.3 nmol/L [5.2-42.4] in successful harvests, vs. median 1.7 nmol/L [0.01-17.9] in unsuccessful harvests). Conclusion(s) Semen cryopreservation should be offered to all pubertal boys diagnosed with cancer. If masturbation fails, electroejaculation can be considered as a useful option for semen cryopreservation and leads to adequate material for cryopreservation in about half of the cases.
KW - childhood cancer
KW - electroejaculation
KW - infertility
KW - Sperm cryopreservation
UR - http://www.scopus.com/inward/record.url?scp=84903395542&partnerID=8YFLogxK
U2 - 10.1016/j.fertnstert.2014.03.038
DO - 10.1016/j.fertnstert.2014.03.038
M3 - Article
C2 - 24780076
AN - SCOPUS:84903395542
SN - 0015-0282
VL - 102
SP - 199-205.e1
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 1
ER -