TY - JOUR
T1 - EMBO Member's review. Cockayne syndrome
T2 - Defective repair of transcription?
AU - Van Gool, Alain J.
AU - Van Der Horst, Gijsbertus T.J.
AU - Citterio, Elisabetta
AU - Hoeijmakers, Jan H.J.
PY - 1997/7/16
Y1 - 1997/7/16
N2 - In the past years, it has become increasingly evident that basal metabolic processes within the cell are intimately linked and influenced by one another. One such link that recently has attracted much attention is the close interplay between nucleotide excision DNA repair and transcription. This is illustrated both by the preferential repair of the transcribed strand of active genes (a phenomenon known as transcription-coupled repair, TCR) as well as by the distinct dual involvement of proteins in both processes. The mechanism of TCR in eukaryotes is still largely unknown. It was first discovered in mammals by the pioneering studies of Hanawalt and colleagues, and subsequently identified in yeast and Escherichia coli. In the latter case, one protein, the transcription repair-coupling factor, was found to accomplish this function in vitro, and a plausible model for its activity was proposed. While the E. coli model still functions as a paradigm for TCR in eukaryotes, recent observations prompt us to believe that the situation in eukaryotes is much more complex, involving dual functionality of multiple proteins.
AB - In the past years, it has become increasingly evident that basal metabolic processes within the cell are intimately linked and influenced by one another. One such link that recently has attracted much attention is the close interplay between nucleotide excision DNA repair and transcription. This is illustrated both by the preferential repair of the transcribed strand of active genes (a phenomenon known as transcription-coupled repair, TCR) as well as by the distinct dual involvement of proteins in both processes. The mechanism of TCR in eukaryotes is still largely unknown. It was first discovered in mammals by the pioneering studies of Hanawalt and colleagues, and subsequently identified in yeast and Escherichia coli. In the latter case, one protein, the transcription repair-coupling factor, was found to accomplish this function in vitro, and a plausible model for its activity was proposed. While the E. coli model still functions as a paradigm for TCR in eukaryotes, recent observations prompt us to believe that the situation in eukaryotes is much more complex, involving dual functionality of multiple proteins.
KW - Cockayne syndrome
KW - Nucleotide excision repair
KW - Review
KW - Transcription-coupled repair
KW - Trichothiodystrophy
KW - Xeroderma pigmentosum
UR - http://www.scopus.com/inward/record.url?scp=0030854714&partnerID=8YFLogxK
U2 - 10.1093/emboj/16.14.4155
DO - 10.1093/emboj/16.14.4155
M3 - Review article
C2 - 9250659
AN - SCOPUS:0030854714
SN - 0261-4189
VL - 16
SP - 4155
EP - 4162
JO - EMBO Journal
JF - EMBO Journal
IS - 14
ER -