Endocrine intervention during irradiation does not prevent damage to the thyroid gland

H. M. Van Santen, J. E. Van Dijk, H. Rodermond, F. Vansenne, E. Endert, J. J.M. De Vijlder, J. Haveman, T. Vulsma

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

6 Citaten (Scopus)


Radiation to the head-neck region may damage the thyroid gland, leading to hypothyroidism or thyroid carcinoma. Outcomes of radiation protection by lowering plasma thyroid-stimulating hormone (TSH) have thus far been ambiguous. Our aim was to evaluate the radioprotective effect of inhibiting the thyroid gland's activity during x-radiation. For this purpose, of 80 5-week old Wistar rats, 64 received cervical irradiation with 15 Gy (single dose). During irradiation, endocrine intervention was done, using thyroxine (T4), T4 plus iodine, or iodine alone compared to placebo. During the endocrine interventions and follow-up, TSH and T4 concentrations were measured periodically. Histologic examination of thyroid, pituitary gland, or the hypothalamus and any suspect lymph nodes, lungs, and liver was performed after 6 and 54 weeks. It was found that during the endocrine intervention, plasma levels of TSH were lower in rats given T4 and higher in rats given iodine. After 6 and 54 weeks, no significant reduction in hypothyroidism or thyroid carcinoma was found between the different groups of rats given any endocrine intervention or no intervention. In conclusion, the administration of T4, iodine or the combination during x-irradiation does not protect against radiation-induced thyroid damage.

Originele taal-2Engels
Pagina's (van-tot)387-395
Aantal pagina's9
Nummer van het tijdschrift4
StatusGepubliceerd - apr. 2006
Extern gepubliceerdJa


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