Samenvatting
Huang, Tailor, et al. show that neuroepithelial stem (NES) cells derived from normal induced pluripotent stem cells (iPSCs) provide a renewable human cell-based resource to evaluate genetic mutations in medulloblastoma. Misexpression of MYCN in both otherwise-normal NES cells and PTCH1+/− NES cells derived from patients with Gorlin syndrome each generated medulloblastoma in mice.
Originele taal-2 | Engels |
---|---|
Pagina's (van-tot) | 433-446.e7 |
Tijdschrift | Cell Stem Cell |
Volume | 25 |
Nummer van het tijdschrift | 3 |
DOI's | |
Status | Gepubliceerd - 5 sep. 2019 |
Extern gepubliceerd | Ja |