Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis

Miller Huang; Jignesh Tailor; Qiqi Zhen; Aaron H. Gillmor; Matthew L. Miller; Holger Weishaupt; Justin Chen; Tina Zheng; Emily K. Nash; Lauren K. McHenry; Zhenyi An; Fubaiyang Ye; Yasuhiro Takashima; James Clarke; Harold Ayetey; Florence M.G. Cavalli; Betty Luu; Branden S. Moriarity; Shirin Ilkhanizadeh; Lukas Chavez; Chunying Yu; Kathreena M. Kurian; Thierry Magnaldo; Nicolas Sevenet; Philipp Koch; Steven M. Pollard; Peter Dirks; Michael P. Snyder; David A. Largaespada; Yoon Jae Cho; Joanna J. Phillips; Fredrik J. Swartling; A. Sorana Morrissy; Marcel Kool; Stefan M. Pfister; Michael D. Taylor; Austin Smith; William A. Weiss

doi:10.1016/j.stem.2019.05.013

Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis

Miller Huang, Jignesh Tailor, Qiqi Zhen, Aaron H. Gillmor, Matthew L. Miller, Holger Weishaupt, Justin Chen, Tina Zheng, Emily K. Nash, Lauren K. McHenry, Zhenyi An, Fubaiyang Ye, Yasuhiro Takashima, James Clarke, Harold Ayetey, Florence M.G. Cavalli, Betty Luu, Branden S. Moriarity, Shirin Ilkhanizadeh, Lukas ChavezChunying Yu, Kathreena M. Kurian, Thierry Magnaldo, Nicolas Sevenet, Philipp Koch, Steven M. Pollard, Peter Dirks, Michael P. Snyder, David A. Largaespada, Yoon Jae Cho, Joanna J. Phillips, Fredrik J. Swartling, A. Sorana Morrissy, Marcel Kool, Stefan M. Pfister, Michael D. Taylor, Austin Smith, William A. Weiss

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Huang, Tailor, et al. show that neuroepithelial stem (NES) cells derived from normal induced pluripotent stem cells (iPSCs) provide a renewable human cell-based resource to evaluate genetic mutations in medulloblastoma. Misexpression of MYCN in both otherwise-normal NES cells and PTCH1^+/− NES cells derived from patients with Gorlin syndrome each generated medulloblastoma in mice.

Originele taal-2	Engels
Pagina's (van-tot)	433-446.e7
Tijdschrift	Cell stem cell
Volume	25
Nummer van het tijdschrift	3
DOI's	https://doi.org/10.1016/j.stem.2019.05.013
Status	Gepubliceerd - 5 sep. 2019
Extern gepubliceerd	Ja

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10.1016/j.stem.2019.05.013

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Huang, M., Tailor, J., Zhen, Q., Gillmor, A. H., Miller, M. L., Weishaupt, H., Chen, J., Zheng, T., Nash, E. K., McHenry, L. K., An, Z., Ye, F., Takashima, Y., Clarke, J., Ayetey, H., Cavalli, F. M. G., Luu, B., Moriarity, B. S., Ilkhanizadeh, S., ... Weiss, W. A. (2019). Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis. Cell stem cell, 25(3), 433-446.e7. https://doi.org/10.1016/j.stem.2019.05.013

@article{a319f4f96558461cba41f4cefa5f649e,

title = "Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis",

abstract = "Huang, Tailor, et al. show that neuroepithelial stem (NES) cells derived from normal induced pluripotent stem cells (iPSCs) provide a renewable human cell-based resource to evaluate genetic mutations in medulloblastoma. Misexpression of MYCN in both otherwise-normal NES cells and PTCH1+/− NES cells derived from patients with Gorlin syndrome each generated medulloblastoma in mice.",

keywords = "SHH, human pluripotent stem cells, medulloblastoma, neuroepithelial stem cells",

author = "Miller Huang and Jignesh Tailor and Qiqi Zhen and Gillmor, \{Aaron H.\} and Miller, \{Matthew L.\} and Holger Weishaupt and Justin Chen and Tina Zheng and Nash, \{Emily K.\} and McHenry, \{Lauren K.\} and Zhenyi An and Fubaiyang Ye and Yasuhiro Takashima and James Clarke and Harold Ayetey and Cavalli, \{Florence M.G.\} and Betty Luu and Moriarity, \{Branden S.\} and Shirin Ilkhanizadeh and Lukas Chavez and Chunying Yu and Kurian, \{Kathreena M.\} and Thierry Magnaldo and Nicolas Sevenet and Philipp Koch and Pollard, \{Steven M.\} and Peter Dirks and Snyder, \{Michael P.\} and Largaespada, \{David A.\} and Cho, \{Yoon Jae\} and Phillips, \{Joanna J.\} and Swartling, \{Fredrik J.\} and Morrissy, \{A. Sorana\} and Marcel Kool and Pfister, \{Stefan M.\} and Taylor, \{Michael D.\} and Austin Smith and Weiss, \{William A.\}",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2019",

month = sep,

day = "5",

doi = "10.1016/j.stem.2019.05.013",

language = "English",

volume = "25",

pages = "433--446.e7",

journal = "Cell stem cell",

issn = "1934-5909",

publisher = "Cell Press",

number = "3",

}

Huang, M, Tailor, J, Zhen, Q, Gillmor, AH, Miller, ML, Weishaupt, H, Chen, J, Zheng, T, Nash, EK, McHenry, LK, An, Z, Ye, F, Takashima, Y, Clarke, J, Ayetey, H, Cavalli, FMG, Luu, B, Moriarity, BS, Ilkhanizadeh, S, Chavez, L, Yu, C, Kurian, KM, Magnaldo, T, Sevenet, N, Koch, P, Pollard, SM, Dirks, P, Snyder, MP, Largaespada, DA, Cho, YJ, Phillips, JJ, Swartling, FJ, Morrissy, AS, Kool, M, Pfister, SM, Taylor, MD, Smith, A & Weiss, WA 2019, 'Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis', Cell stem cell, vol. 25, nr. 3, blz. 433-446.e7. https://doi.org/10.1016/j.stem.2019.05.013

TY - JOUR

T1 - Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis

AU - Huang, Miller

AU - Tailor, Jignesh

AU - Zhen, Qiqi

AU - Gillmor, Aaron H.

AU - Miller, Matthew L.

AU - Weishaupt, Holger

AU - Chen, Justin

AU - Zheng, Tina

AU - Nash, Emily K.

AU - McHenry, Lauren K.

AU - An, Zhenyi

AU - Ye, Fubaiyang

AU - Takashima, Yasuhiro

AU - Clarke, James

AU - Ayetey, Harold

AU - Cavalli, Florence M.G.

AU - Luu, Betty

AU - Moriarity, Branden S.

AU - Ilkhanizadeh, Shirin

AU - Chavez, Lukas

AU - Yu, Chunying

AU - Kurian, Kathreena M.

AU - Magnaldo, Thierry

AU - Sevenet, Nicolas

AU - Koch, Philipp

AU - Pollard, Steven M.

AU - Dirks, Peter

AU - Snyder, Michael P.

AU - Largaespada, David A.

AU - Cho, Yoon Jae

AU - Phillips, Joanna J.

AU - Swartling, Fredrik J.

AU - Morrissy, A. Sorana

AU - Kool, Marcel

AU - Pfister, Stefan M.

AU - Taylor, Michael D.

AU - Smith, Austin

AU - Weiss, William A.

PY - 2019/9/5

Y1 - 2019/9/5

N2 - Huang, Tailor, et al. show that neuroepithelial stem (NES) cells derived from normal induced pluripotent stem cells (iPSCs) provide a renewable human cell-based resource to evaluate genetic mutations in medulloblastoma. Misexpression of MYCN in both otherwise-normal NES cells and PTCH1+/− NES cells derived from patients with Gorlin syndrome each generated medulloblastoma in mice.

AB - Huang, Tailor, et al. show that neuroepithelial stem (NES) cells derived from normal induced pluripotent stem cells (iPSCs) provide a renewable human cell-based resource to evaluate genetic mutations in medulloblastoma. Misexpression of MYCN in both otherwise-normal NES cells and PTCH1+/− NES cells derived from patients with Gorlin syndrome each generated medulloblastoma in mice.

KW - SHH

KW - human pluripotent stem cells

KW - medulloblastoma

KW - neuroepithelial stem cells

UR - https://www.scopus.com/pages/publications/85071524964

U2 - 10.1016/j.stem.2019.05.013

DO - 10.1016/j.stem.2019.05.013

M3 - Article

C2 - 31204176

AN - SCOPUS:85071524964

SN - 1934-5909

VL - 25

SP - 433-446.e7

JO - Cell stem cell

JF - Cell stem cell

IS - 3

ER -

Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis

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