ENU mutagenesis to generate genetically modified rat models.

Ruben van Boxtel, Michael N. Gould, Edwin Cuppen, Bart M.G. Smits

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

26 Citaten (Scopus)

Samenvatting

The rat is one of the most preferred model organisms in biomedical research and has been extremely useful for linking physiology and pathology to the genome. However, approaches to genetically modify specific genes in the rat germ line remain relatively scarce. To date, the most efficient approach for generating genetically modified rats has been the target-selected N-ethyl-N-nitrosourea (ENU) mutagenesis-based technology. Here, we describe the detailed protocols for ENU mutagenesis and mutant retrieval in the rat model organism.

Originele taal-2Engels
Pagina's (van-tot)151-167
Aantal pagina's17
TijdschriftMethods in molecular biology (Clifton, N.J.)
Volume597
DOI's
StatusGepubliceerd - 2010
Extern gepubliceerdJa

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