EPEN-06. YAP1 SUBGROUP SUPRATENTORIAL EPENDYMOMA REQUIRES TEAD AND NUCLEAR FACTOR I-MEDIATED TRANSCRIPTIONAL PROGRAMS FOR TUMORIGENESIS

Keyphrases

• Tumorigenesis 100%
• Myxopapillary Ependymoma 100%
• Transcriptional Program 100%
• Yes-associated Protein 1 (YAP1) 100%
• Nuclear Factor I 100%
• Tead 100%
• MAML1 26%
• Ependymoma 15%
• Tumor 10%
• Transcription Factor 10%
• Oncogenic Function 10%
• Fusion Protein 10%
• YAP1 Fusions 10%
• Pax6 10%
• Molecular Mechanism 5%
• High-level Expression 5%
• Primary Tumor 5%
• Oncogenic Drivers 5%
• Pediatric Brain Tumor 5%
• Nuclear Localization 5%
• Targeted Therapy 5%
• Binding Site 5%
• Supratentorial 5%
• Cancer Types 5%
• Tumor Induction 5%
• Chromatin Immunoprecipitation (ChIP) 5%
• DNA Methylation (DNAm) 5%
• No-report 5%
• Hereafter 5%
• Cortical Progenitor 5%
• Hyperactivity 5%
• Neural Stem Cells 5%
• Histological Analysis 5%
• Binding Motif 5%
• Model Adequacy 5%
• Co-immunoprecipitation (co-IP) 5%
• Dominant-negative Inhibition 5%
• Forced Expression 5%
• In Utero Electroporation 5%
• Structural Rearrangement 5%
• Factor Binding 5%

Neuroscience

• Ependymoma 100%
• Carcinogenesis 100%
• Nuclear Factor I 100%
• Fusion Protein 14%
• Electroporation 7%
• Pediatric Brain Tumor 7%
• Binding Site 7%
• Immunoprecipitation 7%
• PAX6 7%
• Structural Genomics 7%
• DNA Methylation 7%
• Neural Stem Cell 7%
• Enhancer Region 7%
• Nuclear Factor I A 7%

Biochemistry, Genetics and Molecular Biology

• Carcinogenesis 100%
• YAP1 100%
• Nuclear Factor I 100%
• Fusion Protein 9%
• Mouse 4%
• DNA Methylation 4%
• Electroporation 4%
• Stem Cell 4%
• Enhancer Region 4%
• Binding Site 4%
• Immunoprecipitation 4%
• Nuclear Factor I A 4%
• PAX6 4%
• Structural Genomics 4%