Epigenome data release: A participant-centered approach to privacy protection

Stephanie O.M. Dyke, Warren A. Cheung, Yann Joly, Ole Ammerpohl, Pavlo Lutsik, Mark A. Rothstein, Maxime Caron, Stephan Busche, Guillaume Bourque, Lars Rönnblom, Paul Flicek, Stephan Beck, Martin Hirst, Henk Stunnenberg, Reiner Siebert, Jörn Walter, Tomi Pastinen

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

33 Citaten (Scopus)

Samenvatting

Large-scale epigenome mapping by the NIH Roadmap Epigenomics Project, the ENCODE Consortium and the International Human Epigenome Consortium (IHEC) produces genome-wide DNA methylation data at one base-pair resolution. We examine how such data can be made open-access while balancing appropriate interpretation and genomic privacy. We propose guidelines for data release that both reduce ambiguity in the interpretation of open-access data and limit immediate access to genetic variation data that are made available through controlled access.

Originele taal-2Engels
Artikelnummer142
TijdschriftGenome Biology
Volume16
Nummer van het tijdschrift1
DOI's
StatusGepubliceerd - 17 jul. 2015
Extern gepubliceerdJa

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