Epigenome data release: A participant-centered approach to privacy protection

Stephanie O.M. Dyke; Warren A. Cheung; Yann Joly; Ole Ammerpohl; Pavlo Lutsik; Mark A. Rothstein; Maxime Caron; Stephan Busche; Guillaume Bourque; Lars Rönnblom; Paul Flicek; Stephan Beck; Martin Hirst; Henk Stunnenberg; Reiner Siebert; Jörn Walter; Tomi Pastinen

doi:10.1186/s13059-015-0723-0

Epigenome data release: A participant-centered approach to privacy protection

Stephanie O.M. Dyke, Warren A. Cheung, Yann Joly, Ole Ammerpohl, Pavlo Lutsik, Mark A. Rothstein, Maxime Caron, Stephan Busche, Guillaume Bourque, Lars Rönnblom, Paul Flicek, Stephan Beck, Martin Hirst, Henk Stunnenberg, Reiner Siebert, Jörn Walter, Tomi Pastinen

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel › peer review

35 Citaten (Scopus)

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Large-scale epigenome mapping by the NIH Roadmap Epigenomics Project, the ENCODE Consortium and the International Human Epigenome Consortium (IHEC) produces genome-wide DNA methylation data at one base-pair resolution. We examine how such data can be made open-access while balancing appropriate interpretation and genomic privacy. We propose guidelines for data release that both reduce ambiguity in the interpretation of open-access data and limit immediate access to genetic variation data that are made available through controlled access.

Originele taal-2	Engels
Artikelnummer	142
Tijdschrift	Genome biology
Volume	16
Nummer van het tijdschrift	1
DOI's	https://doi.org/10.1186/s13059-015-0723-0
Status	Gepubliceerd - 17 jul. 2015
Extern gepubliceerd	Ja

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Dyke, S. O. M., Cheung, W. A., Joly, Y., Ammerpohl, O., Lutsik, P., Rothstein, M. A., Caron, M., Busche, S., Bourque, G., Rönnblom, L., Flicek, P., Beck, S., Hirst, M., Stunnenberg, H., Siebert, R., Walter, J., & Pastinen, T. (2015). Epigenome data release: A participant-centered approach to privacy protection. Genome biology, 16(1), Artikel 142. https://doi.org/10.1186/s13059-015-0723-0

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abstract = "Large-scale epigenome mapping by the NIH Roadmap Epigenomics Project, the ENCODE Consortium and the International Human Epigenome Consortium (IHEC) produces genome-wide DNA methylation data at one base-pair resolution. We examine how such data can be made open-access while balancing appropriate interpretation and genomic privacy. We propose guidelines for data release that both reduce ambiguity in the interpretation of open-access data and limit immediate access to genetic variation data that are made available through controlled access.",

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doi = "10.1186/s13059-015-0723-0",

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AU - Dyke, Stephanie O.M.

AU - Cheung, Warren A.

AU - Joly, Yann

AU - Ammerpohl, Ole

AU - Lutsik, Pavlo

AU - Rothstein, Mark A.

AU - Caron, Maxime

AU - Busche, Stephan

AU - Bourque, Guillaume

AU - Rönnblom, Lars

AU - Flicek, Paul

AU - Beck, Stephan

AU - Hirst, Martin

AU - Stunnenberg, Henk

AU - Siebert, Reiner

AU - Walter, Jörn

AU - Pastinen, Tomi

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AB - Large-scale epigenome mapping by the NIH Roadmap Epigenomics Project, the ENCODE Consortium and the International Human Epigenome Consortium (IHEC) produces genome-wide DNA methylation data at one base-pair resolution. We examine how such data can be made open-access while balancing appropriate interpretation and genomic privacy. We propose guidelines for data release that both reduce ambiguity in the interpretation of open-access data and limit immediate access to genetic variation data that are made available through controlled access.

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Epigenome data release: A participant-centered approach to privacy protection

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