Epithelioid hemangioendothelioma in children: The European Pediatric Soft Tissue Sarcoma Study Group experience

Daniel Orbach, Max Van Noesel, Bernadette Brennan, Nadège Corradini, Rita Alaggio, Myriam Ben Arush, Reineke A Schoot, Pablo Berlanga, Ilaria Zanetti, Lisa Lyngsie Hjalgrim, Federica Di Corti, Gema Ramirez, Michela Casanova, Andrea Ferrari

Onderzoeksoutput: Bijdrage aan tijdschriftArtikelpeer review

Samenvatting

The European pediatric Soft tissue sarcoma Study Group analyzed all children with epithelioid hemangioendothelioma prospectively registered in the NRSTS-05 (EUDRACT 2005-001139-31) and in MTS-2008 (NCT00379457) studies: 10 patients with localized and one with metastatic disease. Median age was 14.3 years (range, 9.0-18.8). Local therapy was initial primary surgery in seven cases, and five patients received systemic therapy. No patients received radiotherapy. After a median follow-up of 50 months (range, 6-176) for living patients, nine patients remain alive off therapy and two died. Five-year progression free and overall survivals are, respectively, 77.1% (95% confidence interval [CI]: 34.5-93.9) and 74.1% (95% CI: 28.1-93.0).

Originele taal-2Engels
Pagina's (van-tot)e29882
TijdschriftPediatric blood & cancer
DOI's
StatusE-publicatie vóór gedrukte publicatie - 16 jul. 2022

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