Evaluation of a pharmacology-driven dosing algorithm of 3-weekly paclitaxel using therapeutic drug monitoring: A pharmacokinetic-pharmacodynamic simulation study

Keyphrases

• Therapeutic Drug Monitoring 100%
• Dosing Algorithm 100%
• Pharmacokinetics-pharmacodynamics (PK-PD) 100%
• Paclitaxel 100%
• Simulation Study 100%
• Pharmacology 100%
• Weekly Paclitaxel 100%
• Neutropenia 30%
• Body Surface Area 20%
• Plasma Concentration 15%
• Pharmacokinetic-pharmacodynamic Modeling 15%
• Conventional Dose 15%
• Absolute Neutrophil Count 15%
• Population Pharmacokinetics 10%
• NONMEM 10%
• Severe Neutropenia 10%
• Time of Concentration 10%
• First Cycle 10%
• Bilirubin 10%
• Treatment Cycle 10%
• Data Simulation 10%
• Three-compartment Model 10%
• Linear Function 10%
• Mean Error 10%
• Pharmacokinetic Model 5%
• Area-based 5%
• Prospective Clinical Trial 5%
• Prospective Randomized Trial 5%
• Randomized Clinical Trial 5%
• Female Patients 5%
• Saturable 5%
• Subsequent Therapy 5%
• Infectious Complications 5%
• Renal Function 5%
• Sex Body 5%
• Dose Adaptation 5%
• Dose-ranging 5%
• Modeling Software 5%
• Time-varying Data 5%
• Locally Advanced Non-small Cell Lung Cancer (LA-NSCLC) 5%
• Personalized Dosing 5%
• Elimination Capacity 5%
• Count Data 5%
• Restricted Sampling 5%
• Circulating Neutrophils 5%
• Reduced Grade 5%
• Area Function 5%

Pharmacology, Toxicology and Pharmaceutical Science

• Therapeutic Drug Monitoring 100%
• Pharmacodynamics 100%
• Paclitaxel 100%
• Pharmacokinetics 100%
• Neutropenia 34%
• Elimination 13%
• Bilirubin 8%
• Clinical Trial 4%
• Pharmacodynamic Modeling 4%
• NONMEM 4%
• Infectious Complication 4%
• Pharmacokinetic Modeling 4%
• Non Small Cell Lung Cancer 4%
• Randomized Clinical Trial 4%