Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology

Cassandra N. Spracklen; Tugce Karaderi; Hanieh Yaghootkar; Claudia Schurmann; Rebecca S. Fine; Zoltan Kutalik; Michael H. Preuss; Yingchang Lu; Laura B.L. Wittemans; Linda S. Adair; Matthew Allison; Najaf Amin; Paul L. Auer; Traci M. Bartz; Matthias Blüher; Michael Boehnke; Judith B. Borja; Jette Bork-Jensen; Linda Broer; Daniel I. Chasman; Yii Der Ida Chen; Paraskevi Chirstofidou; Ayse Demirkan; Cornelia M. van Duijn; Mary F. Feitosa; Melissa E. Garcia; Mariaelisa Graff; Harald Grallert; Niels Grarup; Xiuqing Guo; Jeffrey Haesser; Torben Hansen; Tamara B. Harris; Heather M. Highland; Jaeyoung Hong; M. Arfan Ikram; Erik Ingelsson; Rebecca Jackson; Pekka Jousilahti; Mika Kähönen; Jorge R. Kizer; Peter Kovacs; Jennifer Kriebel; Markku Laakso; Leslie A. Lange; Terho Lehtimäki; Jin Li; Ruifang Li-Gao; Lars Lind; Jian'an Luan; Leo Pekka Lyytikäinen; Stuart MacGregor; David A. Mackey; Anubha Mahajan; Massimo Mangino; Satu Männistö; Mark I. McCarthy; Barbara McKnight; Carolina Medina-Gomez; James B. Meigs; Sophie Molnos; Dennis Mook-Kanamori; Andrew P. Morris; Renee de Mutsert; Mike A. Nalls; Ivana Nedeljkovic; Kari E. North; Craig E. Pennell; Aruna D. Pradhan; Michael A. Province; Olli T. Raitakari; Chelsea K. Raulerson; Alex P. Reiner; Paul M. Ridker; Samuli Ripatti; Neil Roberston; Jerome I. Rotter; Veikko Salomaa; America A. Sandoval-Zárate; Colleen M. Sitlani; Tim D. Spector; Konstantin Strauch; Michael Stumvoll; Kent D. Taylor; Betina Thuesen; Anke Tönjes; Andre G. Uitterlinden; Cristina Venturini; Mark Walker; Carol A. Wang; Shuai Wang; Nicholas J. Wareham; Sara M. Willems; Ko Willems van Dijk; James G. Wilson; Ying Wu; Jie Yao; Kristin L. Young; Claudia Langenberg; Timothy M. Frayling; Tuomas O. Kilpeläinen; Cecilia M. Lindgren; Ruth J.F. Loos; Karen L. Mohlke

doi:10.1016/j.ajhg.2019.08.001

Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology

Cassandra N. Spracklen, Tugce Karaderi, Hanieh Yaghootkar, Claudia Schurmann, Rebecca S. Fine, Zoltan Kutalik, Michael H. Preuss, Yingchang Lu, Laura B.L. Wittemans, Linda S. Adair, Matthew Allison, Najaf Amin, Paul L. Auer, Traci M. Bartz, Matthias Blüher, Michael Boehnke, Judith B. Borja, Jette Bork-Jensen, Linda Broer, Daniel I. ChasmanYii Der Ida Chen, Paraskevi Chirstofidou, Ayse Demirkan, Cornelia M. van Duijn, Mary F. Feitosa, Melissa E. Garcia, Mariaelisa Graff, Harald Grallert, Niels Grarup, Xiuqing Guo, Jeffrey Haesser, Torben Hansen, Tamara B. Harris, Heather M. Highland, Jaeyoung Hong, M. Arfan Ikram, Erik Ingelsson, Rebecca Jackson, Pekka Jousilahti, Mika Kähönen, Jorge R. Kizer, Peter Kovacs, Jennifer Kriebel, Markku Laakso, Leslie A. Lange, Terho Lehtimäki, Jin Li, Ruifang Li-Gao, Lars Lind, Jian'an Luan, Leo Pekka Lyytikäinen, Stuart MacGregor, David A. Mackey, Anubha Mahajan, Massimo Mangino, Satu Männistö, Mark I. McCarthy, Barbara McKnight, Carolina Medina-Gomez, James B. Meigs, Sophie Molnos, Dennis Mook-Kanamori, Andrew P. Morris, Renee de Mutsert, Mike A. Nalls, Ivana Nedeljkovic, Kari E. North, Craig E. Pennell, Aruna D. Pradhan, Michael A. Province, Olli T. Raitakari, Chelsea K. Raulerson, Alex P. Reiner, Paul M. Ridker, Samuli Ripatti, Neil Roberston, Jerome I. Rotter, Veikko Salomaa, America A. Sandoval-Zárate, Colleen M. Sitlani, Tim D. Spector, Konstantin Strauch, Michael Stumvoll, Kent D. Taylor, Betina Thuesen, Anke Tönjes, Andre G. Uitterlinden, Cristina Venturini, Mark Walker, Carol A. Wang, Shuai Wang, Nicholas J. Wareham, Sara M. Willems, Ko Willems van Dijk, James G. Wilson, Ying Wu, Jie Yao, Kristin L. Young, Claudia Langenberg, Timothy M. Frayling, Tuomas O. Kilpeläinen, Cecilia M. Lindgren, Ruth J.F. Loos, Karen L. Mohlke

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3 Citaten (Scopus)

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(The American Journal of Human Genetics 105, 15–28; July 3, 2019) In the originally published version of this article, the effect sizes for the previously reported loci achieving exome-wide significance (indicated with asterisks in the table below) were incorrect. The table has now been corrected online, and the authors apologize for this error.

Originele taal-2	Engels
Pagina's (van-tot)	670-671
Aantal pagina's	2
Tijdschrift	American Journal of Human Genetics
Volume	105
Nummer van het tijdschrift	3
DOI's	https://doi.org/10.1016/j.ajhg.2019.08.001
Status	Gepubliceerd - 5 sep. 2019

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10.1016/j.ajhg.2019.08.001

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Spracklen, C. N., Karaderi, T., Yaghootkar, H., Schurmann, C., Fine, R. S., Kutalik, Z., Preuss, M. H., Lu, Y., Wittemans, L. B. L., Adair, L. S., Allison, M., Amin, N., Auer, P. L., Bartz, T. M., Blüher, M., Boehnke, M., Borja, J. B., Bork-Jensen, J., Broer, L., ... Mohlke, K. L. (2019). Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology. American Journal of Human Genetics, 105(3), 670-671. https://doi.org/10.1016/j.ajhg.2019.08.001

@article{e64eac45d60b4940bb6e10ff828ca6bd,

title = "Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology",

abstract = "(The American Journal of Human Genetics 105, 15–28; July 3, 2019) In the originally published version of this article, the effect sizes for the previously reported loci achieving exome-wide significance (indicated with asterisks in the table below) were incorrect. The table has now been corrected online, and the authors apologize for this error.",

author = "Spracklen, {Cassandra N.} and Tugce Karaderi and Hanieh Yaghootkar and Claudia Schurmann and Fine, {Rebecca S.} and Zoltan Kutalik and Preuss, {Michael H.} and Yingchang Lu and Wittemans, {Laura B.L.} and Adair, {Linda S.} and Matthew Allison and Najaf Amin and Auer, {Paul L.} and Bartz, {Traci M.} and Matthias Bl{\"u}her and Michael Boehnke and Borja, {Judith B.} and Jette Bork-Jensen and Linda Broer and Chasman, {Daniel I.} and Chen, {Yii Der Ida} and Paraskevi Chirstofidou and Ayse Demirkan and {van Duijn}, {Cornelia M.} and Feitosa, {Mary F.} and Garcia, {Melissa E.} and Mariaelisa Graff and Harald Grallert and Niels Grarup and Xiuqing Guo and Jeffrey Haesser and Torben Hansen and Harris, {Tamara B.} and Highland, {Heather M.} and Jaeyoung Hong and Ikram, {M. Arfan} and Erik Ingelsson and Rebecca Jackson and Pekka Jousilahti and Mika K{\"a}h{\"o}nen and Kizer, {Jorge R.} and Peter Kovacs and Jennifer Kriebel and Markku Laakso and Lange, {Leslie A.} and Terho Lehtim{\"a}ki and Jin Li and Ruifang Li-Gao and Lars Lind and Jian'an Luan and Lyytik{\"a}inen, {Leo Pekka} and Stuart MacGregor and Mackey, {David A.} and Anubha Mahajan and Massimo Mangino and Satu M{\"a}nnist{\"o} and McCarthy, {Mark I.} and Barbara McKnight and Carolina Medina-Gomez and Meigs, {James B.} and Sophie Molnos and Dennis Mook-Kanamori and Morris, {Andrew P.} and {de Mutsert}, Renee and Nalls, {Mike A.} and Ivana Nedeljkovic and North, {Kari E.} and Pennell, {Craig E.} and Pradhan, {Aruna D.} and Province, {Michael A.} and Raitakari, {Olli T.} and Raulerson, {Chelsea K.} and Reiner, {Alex P.} and Ridker, {Paul M.} and Samuli Ripatti and Neil Roberston and Rotter, {Jerome I.} and Veikko Salomaa and Sandoval-Z{\'a}rate, {America A.} and Sitlani, {Colleen M.} and Spector, {Tim D.} and Konstantin Strauch and Michael Stumvoll and Taylor, {Kent D.} and Betina Thuesen and Anke T{\"o}njes and Uitterlinden, {Andre G.} and Cristina Venturini and Mark Walker and Wang, {Carol A.} and Shuai Wang and Wareham, {Nicholas J.} and Willems, {Sara M.} and {Willems van Dijk}, Ko and Wilson, {James G.} and Ying Wu and Jie Yao and Young, {Kristin L.} and Claudia Langenberg and Frayling, {Timothy M.} and Kilpel{\"a}inen, {Tuomas O.} and Lindgren, {Cecilia M.} and Loos, {Ruth J.F.} and Mohlke, {Karen L.}",

note = "Publisher Copyright: {\textcopyright} 2019 American Society of Human Genetics",

year = "2019",

month = sep,

day = "5",

doi = "10.1016/j.ajhg.2019.08.001",

language = "English",

volume = "105",

pages = "670--671",

journal = "American Journal of Human Genetics",

issn = "0002-9297",

publisher = "Cell Press",

number = "3",

}

Spracklen, CN, Karaderi, T, Yaghootkar, H, Schurmann, C, Fine, RS, Kutalik, Z, Preuss, MH, Lu, Y, Wittemans, LBL, Adair, LS, Allison, M, Amin, N, Auer, PL, Bartz, TM, Blüher, M, Boehnke, M, Borja, JB, Bork-Jensen, J, Broer, L, Chasman, DI, Chen, YDI, Chirstofidou, P, Demirkan, A, van Duijn, CM, Feitosa, MF, Garcia, ME, Graff, M, Grallert, H, Grarup, N, Guo, X, Haesser, J, Hansen, T, Harris, TB, Highland, HM, Hong, J, Ikram, MA, Ingelsson, E, Jackson, R, Jousilahti, P, Kähönen, M, Kizer, JR, Kovacs, P, Kriebel, J, Laakso, M, Lange, LA, Lehtimäki, T, Li, J, Li-Gao, R, Lind, L, Luan, J, Lyytikäinen, LP, MacGregor, S, Mackey, DA, Mahajan, A, Mangino, M, Männistö, S, McCarthy, MI, McKnight, B, Medina-Gomez, C, Meigs, JB, Molnos, S, Mook-Kanamori, D, Morris, AP, de Mutsert, R, Nalls, MA, Nedeljkovic, I, North, KE, Pennell, CE, Pradhan, AD, Province, MA, Raitakari, OT, Raulerson, CK, Reiner, AP, Ridker, PM, Ripatti, S, Roberston, N, Rotter, JI, Salomaa, V, Sandoval-Zárate, AA, Sitlani, CM, Spector, TD, Strauch, K, Stumvoll, M, Taylor, KD, Thuesen, B, Tönjes, A, Uitterlinden, AG, Venturini, C, Walker, M, Wang, CA, Wang, S, Wareham, NJ, Willems, SM, Willems van Dijk, K, Wilson, JG, Wu, Y, Yao, J, Young, KL, Langenberg, C, Frayling, TM, Kilpeläinen, TO, Lindgren, CM, Loos, RJF & Mohlke, KL 2019, 'Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology', American Journal of Human Genetics, vol. 105, nr. 3, blz. 670-671. https://doi.org/10.1016/j.ajhg.2019.08.001

TY - JOUR

T1 - Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology

AU - Spracklen, Cassandra N.

AU - Karaderi, Tugce

AU - Yaghootkar, Hanieh

AU - Schurmann, Claudia

AU - Fine, Rebecca S.

AU - Kutalik, Zoltan

AU - Preuss, Michael H.

AU - Lu, Yingchang

AU - Wittemans, Laura B.L.

AU - Adair, Linda S.

AU - Allison, Matthew

AU - Amin, Najaf

AU - Auer, Paul L.

AU - Bartz, Traci M.

AU - Blüher, Matthias

AU - Boehnke, Michael

AU - Borja, Judith B.

AU - Bork-Jensen, Jette

AU - Broer, Linda

AU - Chasman, Daniel I.

AU - Chen, Yii Der Ida

AU - Chirstofidou, Paraskevi

AU - Demirkan, Ayse

AU - van Duijn, Cornelia M.

AU - Feitosa, Mary F.

AU - Garcia, Melissa E.

AU - Graff, Mariaelisa

AU - Grallert, Harald

AU - Grarup, Niels

AU - Guo, Xiuqing

AU - Haesser, Jeffrey

AU - Hansen, Torben

AU - Harris, Tamara B.

AU - Highland, Heather M.

AU - Hong, Jaeyoung

AU - Ikram, M. Arfan

AU - Ingelsson, Erik

AU - Jackson, Rebecca

AU - Jousilahti, Pekka

AU - Kähönen, Mika

AU - Kizer, Jorge R.

AU - Kovacs, Peter

AU - Kriebel, Jennifer

AU - Laakso, Markku

AU - Lange, Leslie A.

AU - Lehtimäki, Terho

AU - Li, Jin

AU - Li-Gao, Ruifang

AU - Lind, Lars

AU - Luan, Jian'an

AU - Lyytikäinen, Leo Pekka

AU - MacGregor, Stuart

AU - Mackey, David A.

AU - Mahajan, Anubha

AU - Mangino, Massimo

AU - Männistö, Satu

AU - McCarthy, Mark I.

AU - McKnight, Barbara

AU - Medina-Gomez, Carolina

AU - Meigs, James B.

AU - Molnos, Sophie

AU - Mook-Kanamori, Dennis

AU - Morris, Andrew P.

AU - de Mutsert, Renee

AU - Nalls, Mike A.

AU - Nedeljkovic, Ivana

AU - North, Kari E.

AU - Pennell, Craig E.

AU - Pradhan, Aruna D.

AU - Province, Michael A.

AU - Raitakari, Olli T.

AU - Raulerson, Chelsea K.

AU - Reiner, Alex P.

AU - Ridker, Paul M.

AU - Ripatti, Samuli

AU - Roberston, Neil

AU - Rotter, Jerome I.

AU - Salomaa, Veikko

AU - Sandoval-Zárate, America A.

AU - Sitlani, Colleen M.

AU - Spector, Tim D.

AU - Strauch, Konstantin

AU - Stumvoll, Michael

AU - Taylor, Kent D.

AU - Thuesen, Betina

AU - Tönjes, Anke

AU - Uitterlinden, Andre G.

AU - Venturini, Cristina

AU - Walker, Mark

AU - Wang, Carol A.

AU - Wang, Shuai

AU - Wareham, Nicholas J.

AU - Willems, Sara M.

AU - Willems van Dijk, Ko

AU - Wilson, James G.

AU - Wu, Ying

AU - Yao, Jie

AU - Young, Kristin L.

AU - Langenberg, Claudia

AU - Frayling, Timothy M.

AU - Kilpeläinen, Tuomas O.

AU - Lindgren, Cecilia M.

AU - Loos, Ruth J.F.

AU - Mohlke, Karen L.

PY - 2019/9/5

Y1 - 2019/9/5

N2 - (The American Journal of Human Genetics 105, 15–28; July 3, 2019) In the originally published version of this article, the effect sizes for the previously reported loci achieving exome-wide significance (indicated with asterisks in the table below) were incorrect. The table has now been corrected online, and the authors apologize for this error.

AB - (The American Journal of Human Genetics 105, 15–28; July 3, 2019) In the originally published version of this article, the effect sizes for the previously reported loci achieving exome-wide significance (indicated with asterisks in the table below) were incorrect. The table has now been corrected online, and the authors apologize for this error.

U2 - 10.1016/j.ajhg.2019.08.001

DO - 10.1016/j.ajhg.2019.08.001

M3 - Comment/debate

C2 - 31491410

AN - SCOPUS:85071704713

SN - 0002-9297

VL - 105

SP - 670

EP - 671

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

IS - 3

ER -

Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology

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